Silben 400 mg (Chewable Tablet)

Unit Price: ৳ 5.00 (1 x 10: ৳ 50.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Albendazole
Company Silco pharmaceutical ltd

Indications

  • Single and mixed infestations of hookworm (Ancylostoma, Necator)
  • Roundworm (Ascaris)
  • Threadworm (Enterobius)
  • Whipworm (Trichuris)
  • Strongyloides
  • Tapeworm
  • Opisthorchi
  • Hydatid

Description

  • Benzimidazole anthelmintic
  • Active against most nematodes and some cestodes
  • Used in the treatment of intestinal nematode infections
  • Used in the treatment of hydatid disease
  • Vermicidal, ovicidal, and larvicidal activity
  • Inhibitory effect on tubulin polymerization

Pharmacology

  • Broad spectrum anthelmintic
  • Exhibits vermicidal, ovicidal, and larvicidal activities
  • Blocks glucose uptake in susceptible helminths
  • Depletes energy level in helminths
  • Exerts anthelmintic effect by immobilizing the parasite
  • Extensively metabolized, probably in the liver
  • Poorly absorbed from the gastrointestinal tract but undergoes extensive first-pass metabolism
  • Principal metabolite albendazole sulphoxide has anthelmintic activity and a plasma half-life of about 8.5 hrs

Dosage & Administration

  • Recommended dose for adults & children over 2 years: 400 mg as a single dose
  • In cases of strongyloidiasis or taeniasis, 400 mg daily for 3 consecutive days
  • Recommended dose for children of 1-2 years: 200 mg as a single dose
  • Not recommended for children under 1 year
  • In hydatid disease: 400 mg twice daily for 28 days for patients over 60 kg
  • For patients less than 60 kg, 15 mg/kg body weight daily in two divided doses

Interaction

  • No reported pharmacodynamic or pharmacokinetic interaction

Contraindications

  • Not normally used in neonates
  • Reduction of the dose from 400 mg to 200 mg may be indicated in children weighing less than 10 kg
  • Not recommended during pregnancy or for women thought to be pregnant
  • No evidence to suggest alteration of dose in renal, hepatic, or cardiac failure

Side Effects

  • Gastrointestinal disturbances
  • Headache
  • Dizziness
  • Changes in liver enzymes
  • Rarely reversible alopecia
  • Rash
  • Fever
  • Blood disorders including leucopenia and pancytopenia
  • Allergic shock if cyst leakage
  • Convulsion and meningism in cerebral disease

Pregnancy & Lactation

  • FDA Pregnancy category of Albendazole is C
  • Should be avoided in pregnancy and lactation unless the potential benefits outweigh the possible risks to the fetus

Precautions & Warnings

  • Blood counts and liver function tests before treatment and twice during each cycle
  • Breastfeeding
  • Exclude pregnancy before starting treatment
  • Constant medical supervision with regular monitoring of serum-transaminase concentrations and leucocyte and platelet counts

Therapeutic Class

  • Anthelmintic

Storage Conditions

  • Keep in a dry place
  • Away from light and heat
  • Keep out of the reach of children

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