Silcona 50 mg (Capsule)

Unit Price: ৳ 8.00 (5 x 4: ৳ 160.00)
Strip Price: ৳ 32.00

Medicine Details

Category Details
Generic Fluconazole
Company Silco pharmaceutical ltd
Also available as
Silcona 150 mg capsule

Indications

  • Vaginal Candidiasis
  • Oropharyngeal Candidiasis
  • Oesophageal Candidiasis
  • Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
  • Kerion
  • Pityriasis versicolor
  • Onychomycosis
  • Invasive candidal infections and cryptococcal infections (including meningitis)
  • Prevention of cryptococcal meningitis
  • Prevention of fungal infections in immunocompromised patients
  • Systemic Candidiasis and Cryptococcal infection
  • Superficial Candidiasis
  • Fungal urinary tract infections
  • Disseminated candidiasis
  • Prophylaxis for fungal infection in neutropenic cancer patients
  • Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis

Pharmacology

Fluconazole is a triazole antifungal agent. It is a potent inhibitor of fungal cytochrome P-450 dependent enzymes. Cytochrome P-450 enzyme system is essential component of fungal cell membrane which is responsible for the synthesis of ergosterol.

Dosage & Administration

  • Adults:
    • Vaginal Candidiasis: 150 mg as a single dose
    • Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
    • Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
    • Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks
    • Kerion: 50 mg daily for 20 days
    • Pityriasis versicolor: 400 mg as a single dose
    • Onychomycosis: 150 mg weekly for 12 months
    • Invasive candidal infections and cryptococcal infections (including meningitis): Orally or by IV infusion, 400 mg on first day then 200-400 mg daily
    • Prevention of cryptococcal meningitis: Orally or by IV infusion 200 mg daily
    • Prevention of fungal infections in immunocompromised patients: Orally or by IV infusion, 50-400 mg daily
  • Use in Specific Population: Elderly patient: The normal dose should be used if there is no evidence of renal impairment. Renal Impairment: No adjustment in single dose therapy is required. In multiple dose therapy of patients with renal impairment, normal doses should be given on days 1 and 2 of treatment and thereafter the dosage intervals should be modified based on creatinine clearance.

Interaction

  • Potential interaction with warfarin - careful monitoring of prothrombin time recommended
  • Interaction with oral sulphonylureas - possibility of hypoglycemic episode should be considered
  • Co-administration of hydrochlorothiazide may increase plasma concentrations of fluconazole
  • Concomitant administration of fluconazole and phenytoin may increase the level of phenytoin
  • Administration of fluconazole and rifampicin has resulted in a decrease in the AUC and shorter half-life of fluconazole
  • Combined oral contraceptive may have varied effects at different dose levels of fluconazole
  • Fluconazole may slowly increase cyclosporin concentrations
  • No clinically significant impairment of fluconazole absorption occurs when co-administered with food, cimetidine, antacids, or following total body irradiation for bone marrow transplantation
  • Administration of fluconazole may decrease the mean plasma clearance of theophylline

Contraindications

Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or to related triazole compounds

Side Effects

  • Common side effects: nausea, abdominal discomfort, diarrhea, flatulence
  • Rare adverse events: rash, anaphylaxis
  • Rare cases of severe cutaneous reactions such as Stevens Johnson Syndrome and toxic epidermal necrolysis

Pregnancy & Lactation

Fluconazole adverse fetal effects have been seen in animals only at dose levels associated with maternal toxicity. It should not be used in pregnancy or in women of childbearing potential unless adequate contraception is employed.

Precautions & Warnings

  • Abnormalities of hepatic, renal, hematological and other biochemical function tests may be observed, particularly in patients with serious underlying diseases such as AIDS and cancer
  • Rare occurrence of exfoliative cutaneous reactions such as Stevens Johnson Syndrome and toxic epidermal necrolysis
  • Discontinuation of fluconazole therapy if a rash develops
  • Use in lactation not recommended
  • Unlikely to impair a patient's ability to drive or use machinery

Use in Special Populations

  • Elderly: The normal dose should be used if there is no evidence of renal impairment
  • Renal Impairment: No adjustments in single dose therapy are required. In multiple dose therapy of patients with renal impairment, the dosage intervals or daily dosage should be modified based on creatinine clearance

Overdose Effects

Supportive measures and symptomatic treatment with gastric lavage if necessary may be adequate. Forced volume diuresis may increase the elimination rate of fluconazole. Hemodialysis may decrease plasma levels by approximately 50%

Therapeutic Class

Drugs for subcutaneous and mycoses

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

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