Tensin 50 mg (Tablet)

Indications

• Hypertension management
• Angina pectoris management
• Hemodynamically stable acute myocardial infarction management

Pharmacology

• Beta1 selective beta-blocker
• Hydrophilic nature
• Poor penetration of cell membranes

Dosage & Administration

• Initial dose for hypertension: 50mg daily
• Initial dose for angina pectoris: 50mg daily
• Initial dose for acute myocardial infarction: 5mg intravenous injection

Interactions

• Catecholamine-depleting drugs additive effect
• Additive effect with calcium channel blockers
• Risk of severe bradycardia with disopyramide
• Additive negative chronotropic effect with amiodarone

Contraindications

• Sinus bradycardia
• Greater than first degree heart block
• Cardiogenic shock
• Overt cardiac failure
• Hypersensitivity to atenolol or components

Side Effects

• Agranulocytosis
• Allergic reactions
• Reversible mental depression
• Mesenteric arterial thrombosis
• Skin rashes
• Dry eyes

Pregnancy & Lactation

• Pregnancy Category D
• Caution during nursing
• Potential adverse effects in breast-fed infants

Precautions & Warnings

• Careful evaluation for patients already on beta blocker
• Aggravation of peripheral arterial circulatory disorders
• Caution in impaired renal function
• Dose adjustment for elderly patients

Use in Special Populations

• Dosage adjustment for elderly patients
• Dosage adjustment for renal impaired patients

Overdose Effects

• Reported overdoses up to 5g
• Symptoms include lethargy, respiratory disorder, wheezing, sinus pause, bradycardia

Therapeutic Class

• Beta-adrenoceptor blocking drugs
• Beta-blockers

Storage Conditions

• Do not use after expiry date
• Keep out of reach of children
• Dispense only with prescription

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