Levetira 500 mg/5 ml (Oral Solution)

100 ml bottle: ৳ 400.00

Medicine Details

Category Details
Generic Levetiracetam
Company Popular pharmaceuticals ltd
Also available as
Levetira 500 mg tablet

Title and Categories

  • Levetira
  • Medicine
  • Antiepileptic Drug
  • Adjunct Drug

Age Group

  • Adults
  • Adolescents
  • Children
  • Infants

Indication

  • Monotherapy for partial-onset seizures in adults and adolescents from 16 years
  • Adjunctive therapy for partial-onset seizures in adults, adolescents, children, and infants from 1 month
  • Treatment of myoclonic seizures in adults and adolescents from 12 years
  • Treatment of primary generalized tonic-clonic seizures in adults and adolescents from 12 years

Mechanism of Action

  • Precise mechanism unknown
  • Minimal activity in submaximal stimulation and threshold tests
  • Inhibition of burst firing without affecting normal neuronal excitability

Dosage

  • Initial starting dose of 250 mg twice daily for adults and adolescents from 16 years
  • Maximum dose of 1500 mg twice daily for adults and adolescents
  • Initial therapeutic dose of 500 mg twice daily for adults and adolescents (≥18 years) and weighing 50 kg or more
  • Use of oral solution for pediatric population

Administration

  • Oral administration
  • Swallowed with sufficient liquid
  • Can be taken with or without food
  • Administered in two equally divided doses

Interaction

  • No influence on serum concentrations of existing antiepileptic medicinal products
  • Inhibition of renal clearance of the primary metabolite by probenecid
  • Decreased methotrexate clearance when used concomitantly with Levetira

Contraindications

  • Hypersensitivity to active substance or excipients

Side Effects

  • Most common adverse reactions: somnolence, asthenia, infection, dizziness (adults)
  • Most common adverse reactions: fatigue, aggression, nasal congestion, decreased appetite, irritability (pediatric)

Pregnancy & Lactation

  • Not recommended during pregnancy
  • Excretion in human breast milk
  • Impact on fertility unknown

Precautions & Warnings

  • Dose adjustment in renal impairment
  • Rare cases of decreased blood cell counts
  • Association with suicidal ideation and behavior
  • Tablet formulation not adapted for use in infants and children under 6 years

Special Populations

  • Elderly (65 years and older)
  • Renal impairment
  • Hepatic impairment

Overdose Effects

  • Somnolence
  • Agitation
  • Respiratory depression
  • Coma
  • No specific antidote

Therapeutic Class

  • Adjunct anti-epileptic drugs

Storage Conditions

  • Cool temperature not exceeding 25°C
  • Dry place
  • Protected from light

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