Akicin 100 mg/2 ml (IM/IV Injection)

Title and Categories

• Amikacin Injection
• Antibiotic
• Aminoglycosides

Indications

• Treatment of serious infections due to susceptible strains of Gram-negative bacteria
• Effective in bacterial septicemia, respiratory tract infections, bone and joint infections, central nervous system infections, skin and soft tissue infections, intra-abdominal infections, burns, postoperative infections
• Effective in treating infections caused by gentamicin and/or tobramycin-resistant strains
• Effective in staphylococci infections
• Effective in serious complicated and recurrent urinary tract infections

Pharmacology

• Semi-synthetic aminoglycoside antibiotic
• Active against pseudomonas species, Escherichia coli, Proteus species, Providencia species, Klebsiella-Enterobacter species, Acinetobacter species, and Citrobacter freundii
• Active against penicillinase and nonpenicillinase-producing Staphylococcus species

Dosage

• Adult dose: 15 mg/kg/day in two equally-divided doses
• Neonates and premature children: Initial loading dose of 10 mg/kg followed by 15 mg/kg/day in two equally divided doses
• Dosage adjustment for elderly and impaired renal function patients
• Increased dose for life-threatening infections and/or those caused by Pseudomonas
• Urinary tract infections dosage: 7.5mg/kg/day in two equally divided doses

Administration

• Preferred intramuscular route for most infections
• Intravenous route for life-threatening infections or when intramuscular injection route is not feasible
• Intraperitoneal use as an irrigant after recovery from anesthesia

Interaction

• Potentiation of myorelaxants effects
• Avoid combination with other Aminoglycoside antibiotics
• Increased ototoxicity risk with fast-acting diuretics in patients with renal failure
• Increased nephrotoxicity risk with Cephalosporins or Polymixins combination

Contraindications

• Hypersensitivity to Amikacin or any constituents of the injection

Side Effects

• Tinnitus
• Vertigo
• Reversible or irreversible deafness
• Skin rash
• Drug fever
• Headache
• Paraesthesia
• Nausea
• Vomiting

Pregnancy & Lactation

• Potential risk of ototoxicity in the fetus due to placental transfer
• No safety information available for breastfeeding

Precautions & Warnings

• High concentrations in renal excretory system
• Ensure adequate hydration to minimize chemical irritation of renal tubules
• Monitor renal function during treatment

Use in Special Populations

• Safety and effectiveness not established for children or adolescents under 16 years

Overdose Effects

• Peritoneal dialysis or haemodialysis for removal of Akicin from the blood

Therapeutic Class

• Aminoglycosides

Storage Conditions

• Below 30°C temperature
• Away from light and moisture
• Keep out of the reach of children

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