Peptex 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 8.00 (4 x 10: ৳ 320.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Esomeprazole
Company Dbl pharmaceuticals ltd
Also available as
Peptex 40 mg capsule

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Treatment of Zollinger-Ellison Syndrome
  • Treatment of Acid-related Dyspepsia
  • Treatment of Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppression of gastric acid secretion
  • Inhibition of H+/K+-ATPase
  • Extensive metabolism in the liver
  • Enteric-coated pellet formulation
  • Absorption peak at approximately 1.5 hours
  • 97% bound to plasma proteins
  • Metabolized by the cytochrome P450 (CYP) enzyme system
  • Plasma elimination half-life of approximately 1-1.5 hours

Dosage

  • 20 mg or 40 mg Once Daily for 4-8 Weeks for healing of erosive esophagitis
  • 20 mg Once Daily for maintenance of healing of erosive esophagitis
  • 20 mg Once Daily for Symptomatic GERD
  • 40 mg Once Daily for 10 days for Helicobacter pylori eradication
  • 20-80 mg once daily for Zollinger-Ellison Syndrome
  • 20-40 mg once daily for 2-4 weeks for Acid-related Dyspepsia
  • 20 mg once daily for 2-4 weeks for Duodenal ulcer
  • 20-40 mg once daily for 4-8 weeks for Gastric ulcer
  • IV Injection: >3 Minutes, IV Infusion: 10-30 minutes

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral suspension should be taken with water and consumed within 30 minutes
  • IV injection should be administered intravenously over a period of at least 3 minutes

Interaction

  • Metabolized by CYP2C19 and CYP3A4
  • Potential interference with CYP2C19
  • Possible interference with the absorption of certain drugs

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No known excretion in milk
  • Breastfeeding should be discontinued if essential

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Guidelines for patients with difficulty swallowing capsules
  • Usage of antacids concurrently

Use in Special Populations

  • Safety and effectiveness in paediatric patients not established
  • No overall differences in safety and efficacy for the elderly
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Expected unaltered pharmacokinetics in patients with renal impairment

Overdose Effects

  • Major signs of acute toxicity in rats
  • No specific antidote known
  • Expected lack of removal by dialysis

Storage Conditions

  • Store at a temperature not exceeding 30°C
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure: Image URL

Common Questions about Peptex 20 mg Capsule

  • What is Peptex 20 mg Capsule?: Description of the proton pump inhibitor (PPI) and its uses
  • What is Peptex 20 mg Capsule used for?: Various uses for heartburn, GERD, and erosive esophagitis
  • What are the side effects of Peptex 20 mg Capsule?: List of common side effects
  • Can I take Peptex 20 mg Capsule if I am pregnant or breastfeeding?: Information on its use during pregnancy and breastfeeding
  • How long does it take for Peptex 20 mg Capsule to work?: Expected onset of action within a few hours

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