Rabenta 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 8.00 (4 x 10: ৳ 320.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Rabeprazole sodium
Company Dbl pharmaceuticals ltd

Indications

  • Active duodenal ulcer
  • Active benign gastric ulcer
  • Symptomatic erosive or ulcerative gastro-esophageal reflux disease (GERD)
  • Gastro-esophageal Reflux Disease Long-term Management (GERD Maintenance)
  • Symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
  • Zollinger-Ellison Syndrome
  • In combination with appropriate antibacterial therapeutic regimens for the eradication of Helicobacter pylori in patients with peptic ulcer disease

Pharmacology

  • Suppresses gastric acid secretion
  • Inhibits the gastric H+/K+-ATPase

Dosage

  • 20 mg for active duodenal ulcer and active benign gastric ulcer once daily in the morning
  • 20 mg for erosive or ulcerative gastro-esophageal reflux disease once daily for 4-8 weeks
  • Maintenance dose of 20 mg or 10 mg once daily for long-term management

Administration

  • To be taken in the morning before eating
  • Tablets should not be chewed or crushed, but swallowed whole

Interaction

  • Potential interaction with pH-dependent absorption compounds
  • Decrease in antifungal plasma levels when co-administered with ketoconazole or itraconazole
  • No interaction with liquid antacids observed
  • Absorption of atazanavir is pH-dependent, hence should not be co-administered with rabeprazole

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Contra-indicated in pregnancy and during breastfeeding

Side Effects

  • Headache
  • Diarrhoea
  • Abdominal pain
  • Vomiting
  • Constipation
  • Dry mouth
  • Increased or decreased appetite
  • Muscle pain
  • Drowsiness
  • Dizziness

Pregnancy & Lactation

  • US FDA pregnancy category 'C'
  • No adequate and well-controlled studies in pregnant women
  • Likely excreted in human milk

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric or esophageal malignancy
  • Modestly increased risk of hip, wrist and spine fracture in high doses and over long durations
  • Risk of cross-hypersensitivity reactions
  • Risk of blood dyscrasias, hepatic enzyme abnormalities, and hypomagnesaemia
  • Reduced absorption of vitamin B12
  • Association with subacute cutaneous lupus erythematosus (SCLE)
  • Interference with laboratory tests

Use in Special Populations

  • No dosage adjustment for patients with renal or hepatic impairment
  • Not recommended for use in children due to lack of data on safety and efficacy

Overdose Effects

  • Maximum established exposure is 60 mg twice daily or 160 mg once daily
  • Effects are generally minimal and reversible without further medical intervention
  • No specific antidote known

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep below 30°C temperature, away from light & moisture, and out of the reach of children

Chemical Structure

  • Molecular Formula: C18H21N3O3S

Common Questions about Rabenta 20 mg Capsule

  • Used to treat duodenal ulcer, gastric ulcer, GERD, Zollinger-Ellison Syndrome, Helicobacter pylori eradication
  • Side effects include diarrhea, constipation, nausea, vomiting, headache, dizziness, rash, dry mouth, kidney problems, liver damage, and bone fractures
  • Should be taken with food, not recommended during pregnancy or breastfeeding
  • Overdose can cause drowsiness, confusion, and seizures
  • Long-term use can cause thinning of bones (osteoporosis), and decrease in vitamin B12 and calcium absorption

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