Alphalok XR 2.5 mg (Tablet (Extended Release))

Unit Price: ৳ 10.00 (2 x 14: ৳ 280.00)
Strip Price: ৳ 140.00

Medicine Details

Category Details
Generic Prazosin hydrochloride
Company Opsonin pharma ltd
Also available as
Alphalok 1 mg tablet Alphalok 2 mg tablet Alphalok xr 5 mg tablet

Indications

  • Hypertension
  • Left Ventricular Failure
  • Raynaud's Phenomenon
  • Raynaud's Disease
  • Benign Prostatic Hyperplasia

Pharmacology

  • Selective inhibition of alpha-1-adrenoreceptors
  • Reduction in total peripheral vascular resistance
  • Reduction in left ventricular filling pressure
  • Reduction in cardiac impedance
  • Augmentation of cardiac output

Dosage & Administration

  • Adjustable dosage based on patient's response
  • Use with diuretic and/or other antihypertensive drugs
  • Initial low starting dose for best toleration

Interaction

  • No adverse drug interaction observed in clinical experience to date
  • Not reported to interact adversely with common medication classes

Contraindications

  • Known sensitivity to quinazolines

Side Effects

  • Dizziness
  • Headache
  • Drowsiness
  • Weakness
  • Palpitations
  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal discomfort
  • Liver function abnormalities
  • Pancreatitis
  • Edema
  • Orthostatic hypotension
  • Dyspnea
  • Faintness
  • Tachycardia
  • Nervousness
  • Vertigo
  • Hallucinations
  • Depression
  • Rash
  • Pruritus
  • Alopecia

Pregnancy & Lactation

  • No teratogenic effects seen in animal testing
  • Excretion in small amounts in human milk
  • Caution in use during pregnancy and nursing

Precautions & Warnings

  • Postural hypotension risk at initial dose
  • Gradual titration is important to prevent fluid retention
  • Monitoring blood pressure during administration and adjustment of dose

Use in Special Populations

  • Not recommended for children under 12 years
  • Not recommended for left ventricular failure due to mechanical obstruction
  • Efficacy not established for left ventricular failure due to recent myocardial infarction

Overdose Effects

  • Profound drowsiness and depressed reflexes observed
  • No decrease in blood pressure noted in case of accidental ingestion by a child
  • Cardiovascular system support of first importance in case of hypotension

Therapeutic Class

  • Alpha adrenoceptor blocking drugs

Storage Conditions

  • Keep away from light and moisture
  • Store below 30°C
  • Keep out of reach of children

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