Alphalok XR 5 mg (Tablet (Extended Release))
Unit Price: ৳ 15.00 (2 x 14: ৳ 420.00)
Strip Price: ৳ 210.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Prazosin hydrochloride |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Treatment of essential hypertension
- Treatment of secondary hypertension
- Treatment of left ventricular failure
- Treatment of Raynaud's phenomenon and disease
- Adjunct treatment for benign prostatic hyperplasia
Pharmacology
- Decrease in total peripheral vascular resistance
- Selective inhibition of alpha-1-adrenoreceptors
- Lowering of blood pressure in supine and standing positions
- Reduction in left ventricular filling pressure
- Reduction in cardiac impedance
- Augmentation of cardiac output
Dosage & Administration
- Initiate therapy with a low starting dose
- Adjust dosage based on patient's response
- Recommended starting dose for left ventricular failure
- Recommended starting dosage for Raynaud's phenomenon
- Recommended starting dosage for benign prostatic hyperplasia
- Dosage titration steps for left ventricular failure
Interaction
- No adverse drug interaction observed with
- Cardiac-glycosides-digitalis and digoxin
- Hypoglycemic agents-insulin, chlorpropamide, phenformin, tolazamide, and tolbutamide
- Tranquilizers and sedatives-chlordiazepoxide, diazepam and phenobarbital
- Antiarrhythmic agents-procainamide, propranolol and quinidine
- Analgesic, antipyretic, and anti-inflammatory agents-propxyphene, aspirin, indomethacin, and phenylbutazone type
Contraindications
- Known sensitivity to quinazolines
Side Effects
- Dizziness
- Headache
- Drowsiness
- Weakness
- Palpitations
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Abdominal discomfort and/or pain
- Liver function abnormalities
- Pancreatitis
- Edema
- Orthostatic hypotension
- Dyspnea
- Faintness
- Tachycardia
- Nervousness
- Vertigo
- Hallucinations
- Depression
- Rash
Pregnancy & Lactation
- No teratogenic effects seen in animal testing
- Safety in pregnancy not yet established
- Excretion in small amounts in human milk
- Caution when administered to nursing mothers
Precautions & Warnings
- Postural hypotension in hypertensive patients
- Decrease in left ventricular filling pressure in left ventricular failure
- Careful monitoring of blood pressure during initial administration
Use in Special Populations
- Not recommended for children under 12 years
- Not recommended in left ventricular failure due to mechanical obstruction
- Efficacy not established in left ventricular failure due to recent myocardial infarction
Overdose Effects
- Accidental ingestion results in profound drowsiness
- No decrease in blood pressure noted
- Cardiovascular system support is of first importance
- Renal function monitoring and support
Therapeutic Class
- Alpha adrenoceptor blocking drugs
Storage Conditions
- Keep away from light and moisture
- Store below 30°C
- Keep away from reach of children