Xenovate 0.05% (Scalp Solution)

30 ml bottle: ৳ 250.00

Medicine Details

Category	Details
Generic	Clobetasol propionate
Company	Unimed unihealth pharmaceuticals ltd
Also available as	Xenovate 005 cream Xenovate 005 ointment

Indications

Psoriasis (excluding widespread plaque psoriasis)
Recalcitrant dermatoses
Lichen planus
Discoid lupus erythematosus
Other skin conditions which do not respond satisfactorily to less potent steroids
Suitable for adults, elderly, and children over 1 year

Composition

Clobetasol Propionate Cream: Each gram contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Clobetasol Propionate Ointment: Each gram contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Clobetasol Propionate Scalp Application: Each gram contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Clobetasol Propionate Shampoo: Each gram contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Clobetasol Propionate Lotion: Each gram contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Clobetasol Propionate Spray: Each gram contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)

Pharmacology

Very potent topical corticosteroid with anti-inflammatory, antipruritic and vasoconstrictive properties
Shows anti-inflammatory activity via multiple mechanisms to inhibit late phase allergic reactions
Reduces cytokine production and inhibits the metabolism of arachidonic acid

Dosage

Cream and Ointment: Apply a thin layer to affected skin areas twice daily
Super-high potency topical corticosteroids - treatment should be limited to 2 consecutive weeks
Maximum weekly dose should not exceed 50 gm/week
Spray: Apply once or twice daily to affected areas of the scalp
Total dose applied should not exceed 50 ml weekly
Shampoo: Applied to dry scalp once a day for 4 consecutive weeks

Administration

Route of administration: Cutaneous. Creams are especially appropriate for moist or weeping surfaces. Ointments are especially appropriate for dry, lichenified or scaly lesions

Interaction

Co-administered drugs that can inhibit CYP3A4 may inhibit the metabolism of corticosteroids

Contraindications

Rosacea, acne vulgaris and perioral dermatitis
Hypersensitivity to the preparation
Not indicated for treatment of primarily infected skin lesions caused by infection with fungi or bacteria
Dermatoses in children under one year of age

Side Effects

Prolonged use of large amounts can result in systemic absorption
Local atrophic changes in the skin
Reports of pigmentation changes and hypertrichosis
Well tolerated, but signs of hypersensitivity may occur

Pregnancy & Lactation

Limited data in pregnant women
Caution should be exercised when administered to a nursing woman

Precautions & Warnings

Long-term continuous therapy should be avoided, particularly in infants and children
Atrophic changes may occur after prolonged treatment on the face
Care is needed to ensure that the preparation does not enter the eye if applied to the eyelids
Hazardous in psoriasis for a number of reasons

Use in Special Populations

Long-term continuous therapy should be avoided in infants and children under 12 years of age