Trental 400 mg (Tablet (Controlled Release))

Indications

• Peripheral arterial occlusive disease (PAOD) of arteriosclerotic or diabetic origin
• Trophic lesions (e.g. leg ulcers and gangrene)
• Cerebral vascular diseases
• Circulatory disturbances of the eye in conjunction with degenerative vascular disorders

Pharmacology

• Improves flow properties of blood
• Decreases blood viscosity
• Increases blood flow to affected microcirculation
• Enhances tissue oxygenation
• Improves erythrocyte flexibility
• Modifies leukocyte properties
• Increases leukocyte deformability
• Inhibits neutrophil adhesion and activation
• Increases tissue oxygen levels

Dosage & Administration

• Usual dosage is 400 mg pentoxifylline 2 to 3 times daily
• Tablets are to be swallowed whole during or shortly after a meal with sufficient amounts of liquid

Interaction

• Blood-sugar-lowering effect potentiation
• Increased anti-coagulant activity
• Blood-pressure-lowering effect potentiation
• Increased theophylline levels
• Increased serum concentration
• Potential additive effect with platelet aggregation inhibitors
• Increased plasma concentration

Contraindications

• Hypersensitivity to pentoxifylline or other methylxanthines
• Massive bleeding
• Extensive retinal bleeding

Side Effects

• Transaminases increased
• Blood pressure decreased
• Arrhythmia
• Tachycardia
• Thrombocytopenia
• Dizziness
• Headache
• Gastrointestinal disorders
• Pruritus
• Erythema
• Urticaria
• Hot flush
• Haemorrhage
• Anaphylactic reaction
• Cholestasis
• Agitation
• Sleep disorder

Pregnancy & Lactation

• Not recommended during pregnancy
• Passes into breast milk in minute quantities

Precautions & Warnings

• Discontinue at first signs of anaphylactic/anaphylactoid reaction
• Careful monitoring required for various patient conditions
• Dose reduction required in hepatic impairment
• Dose reduction required in renal impairment
• Start treatment at low-dose levels in hypotensive patients

Use in Special Populations

• Dose reduction necessary in hepatic impairment
• Dose reduction necessary in renal impairment
• Low-dose start for hypotensive patients

Overdose Effects

• Nausea
• Dizziness
• Tachycardia
• Fall in blood pressure
• Fever
• Agitation
• Loss of consciousness
• Areflexia
• Tonic-clonic convulsions
• Gastrointestinal bleeding
• Coffee-ground vomiting
• No specific antidote is known

Therapeutic Class

• Peripheral Vasodilator drugs: Intermittent Claudication

Storage Conditions

• Keep in a cool and dry place
• Away from light
• Do not use later than date of expiry
• Keep out of the reach of children
• To be dispensed only on the prescription of a registered physician

Related Brands

• Oxifyl CR 400 mg (Tablet (Controlled Release)) - square-pharmaceuticals-plc