Linexil 400 mg (Tablet)

Unit Price: ৳ 60.00 (2 x 10: ৳ 1,200.00)
Strip Price: ৳ 600.00

Medicine Details

Category Details
Generic Linezolid
Company Opsonin pharma ltd
Also available as
Linexil 600 mg tablet Linexil 100 mg suspension Linexil 2 mg injection

Title

  • Linexil

Categories

  • Medicine
  • Antibiotic
  • Pharmaceutical

Description

  • This product is indicated for the treatment of nosocomial pneumonia, community-acquired pneumonia, complicated skin and skin structure infections, uncomplicated skin and skin structure infections, and vancomycin-resistant Enterococcus faecium infections.

Indications

  • Nosocomial pneumonia
  • Community-acquired pneumonia
  • Complicated skin and skin structure infections
  • Uncomplicated skin and skin structure infections
  • Vancomycin-resistant Enterococcus faecium infections

Pharmacology

  • Linezolid is a synthetic antibacterial agent
  • In vitro activity against Gram-positive aerobes and some anaerobes
  • Selectively inhibits bacterial protein synthesis
  • Bacteriostatic against enterococci and staphylococci
  • Bactericidal for the majority of streptococci strains

Dosage & Administration

  • Can be taken orally with or without food
  • Intravenous infusion over 30 to 120 minutes
  • Dosage varies based on infection and age group
  • No dose adjustment needed when switching from IV to oral administration
  • Hepatic impairment: no dose adjustment recommended for mild-to-moderate impairment

Interaction

  • Reversible, nonselective inhibitor of monoamine oxidase
  • Potential for interaction with adrenergic and serotonergic agents
  • Patients should avoid large quantities of foods with high tyramine content while taking this medication

Contraindications

  • Known hypersensitivity to Linezolid or other product components
  • Contraindicated with monoamine oxidase inhibitors or within two weeks of taking such medication
  • Not for patients with uncontrolled hypertension, pheochromocytoma, thyrotoxicosis, or taking certain sympathomimetic or serotonergic agents

Side Effects

  • Most common: diarrhea, headache, nausea
  • Other adverse events include oral and vaginal moniliasis, hypertension, dyspepsia, localized abdominal pain, pruritus, and tongue discoloration

Pregnancy & Lactation

  • Limited data on use in pregnancy
  • Present in breast milk
  • Consider benefits of breastfeeding against potential risk to the child

Precautions & Warnings

  • Monitor complete blood counts in patients receiving Linezolid
  • Prompt ophthalmic evaluation if symptoms of visual impairment occur
  • Not approved for catheter-related infections
  • C. difficile-associated diarrhea may occur
  • Careful use in patients with certain medical conditions or on specific medications
  • Regular monitoring for potential increases in blood pressure
  • Immediate medical evaluation if certain symptoms occur
  • Potential need for dose adjustments if hypoglycemia occurs

Overdose Effects

  • No cases reported
  • Symptomatic and supportive care advised, along with maintenance of glomerular filtration

Therapeutic Class

  • Macrolides

Reconstitution

  • For oral suspension: add boiled and cooled water to the dry mixture in the bottle
  • Shake well before use
  • Use within 21 days after constitution
  • For intravenous administration, supplied in ready-to-use infusion bottles
  • Avoid introduction of additives into the solution

Storage Conditions

  • Store at room temperature (15°C-30°C)
  • Protect from light and moisture
  • Keep away from children

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