Parkitrol 5 mg (Tablet)
Unit Price: ৳ 10.00 (5 x 10: ৳ 500.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Sun pharmaceutical bangladesh ltd |
| Also available as |
Indications
- Adjunct in treatment of parkinsonism
- Adjuvant therapy with levodopa
- Control of extrapyramidal disorders
Description
- Direct inhibitory effect on parasympathetic nervous system
- Relaxing effect on smooth musculature
Pharmacology
- Muscarinic acetylcholine receptor antagonist
- Higher affinity for central muscarinic receptors
- Lower affinity for peripheral muscarinic receptors
- Modifies nicotinic acetylcholine receptor neurotransmission
- Enhanced dopamine release in striatum
Dosage & Administration
- Individualized dosage
- Initial low dose with gradual increase
- Adjustment based on patient reaction
- Preferable administration before or after meals
- Dose management for different forms of parkinsonism
- Dose adjustment in concomitant use with levodopa
- Optimal dosing for children not established
Interaction
- Additive effects with cannabinoids, barbiturates, opiates, alcohol
- Increased sedative effects with alcohol or CNS depressants
- Intensification of anticholinergic effects with monoamine oxidase inhibitors, tricyclic antidepressants
- Increased risk for tardive dyskinesia with concurrent administration of anticholinergics and neuroleptics
Contraindications
- Hypersensitivity to trihexyphenidyl
- Narrow angle glaucoma
Side Effects
- Dryness of the mouth
- Blurred vision
- Dizziness
- Nausea
- Nervousness
- Suppurative parotitis
- Skin rashes
- Dilatation of the colon
- Paralytic ileus
- Psychiatric manifestations
- Cognitive dysfunctions
- Constipation
- Drowsiness
- Urinary hesitancy
- Tachycardia
- Dilation of the pupil
- Increased intraocular pressure
- Choreiform movements
- Weakness
- Vomiting
- Headache
- Exacerbation of parkinsonism with abrupt withdrawal
- Neuroleptic malignant syndrome with abrupt withdrawal
- Angle-closure glaucoma
- Paradoxical sinus bradycardia
- Dry skin
- Cycloplegia
Pregnancy & Lactation
- Use only if benefit outweighs risk during pregnancy
- Caution in nursing women
- Potential suppression of lactation
Precautions & Warnings
- Gonioscope evaluation prior to therapy
- Close monitoring of intraocular pressures
- Possible angle closure and increase in intraocular pressure
- Caution in hot weather, alcoholics, those with CNS disease, and manual laborers in hot environments
- Potential for anhidrosis and hyperthermia
- Possible occurrence of Neuroleptic Malignant Syndrome
Overdose Effects
- Central anticholinergic syndrome
- Dilated and sluggish pupils
- Warm, dry skin
- Facial flushing
- Decreased secretions
- Foul-smelling breath
- Elevated temperature
- Tachycardia
- Cardiac arrhythmias
- Decreased bowel sounds
- Urinary retention
- Neuropsychiatric signs
- Stupor
- Coma
- Paralysis
- Cardiac and respiratory arrest
- Symptomatic and supportive therapy for treatment
- Gastric lavage or other methods to limit absorption
- Administration of diazepam or a short-acting barbiturate if CNS excitation is observed
- Contraindication of phenothiazines
- Respiratory support and vasopressor agents may be necessary
- Reversal of hyperpyrexia, fluid volume replacement, and acid-balance maintenance
- Unknown dialyzability
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Temperature not exceeding 30°C
- Dry place
- Protection from light