Metaloc 100 mg (Tablet)
Unit Price: ৳ 2.51 (5 x 10: ৳ 125.50)
Strip Price: ৳ 25.10
Medicine Details
| Category | Details |
|---|---|
| Generic | Metoprolol tartrate |
| Company | Renata limited |
| Also available as |
Indications
- Hypertension management
- Treatment of angina pectoris
- Management of cardiac arrhythmias
- Adjunct to the treatment of hyperthyroidism
- Reduction of infarct size in acute myocardial infarction
- Pain relief
- Reduction of mortality in acute myocardial infarction
Pharmacology
- Selective beta1-blocker
- Reduction of heart rate
- Inhibition of catecholamines
- Reduction of cardiac output
- Interference with insulin release
- Interference with carbohydrate metabolism
Dosage & Administration
- Total daily dosage range: 100-400 mg
- Initial dose: 100 mg/day
- Dose escalation at weekly intervals
- Twice or thrice daily dosing for angina
- Control of cardiac arrhythmias with 50-300 mg/day
- Four times daily dosing for hyperthyroidism
- Initial oral dose for myocardial infarction: 50 mg every 6 hours for 48 hours
Interaction
- Additive effect with catecholamine-depleting drugs
- Increased concentration with CYP2D6 inhibitors
- Risk of bradycardia with concomitant digitalis glycosides
- Exacerbation of rebound hypertension with clonidine withdrawal
Contraindications
- AV block
- Uncontrolled heart failure
- Severe bradycardia
- Sick-sinus syndrome
- Cardiogenic shock
- Severe peripheral arterial disease
- Known hypersensitivity to Metoprolol or other B-blockers
- Complicated myocardial infarction with significant bradycardia
- First-degree heart block
- Systolic hypotension
- Severe heart failure
Side Effects
- Tiredness
- Dizziness
- Depression
- Diarrhea
- Itching or rash
- Shortness of breath
- Slow heart rate
- Mental confusion
- Headache
- Somnolence
- Nightmares
- Insomnia
- Dyspnea
- Nausea
- Dry mouth
- Gastric pain
- Constipation
- Flatulence
- Heartburn
- Pruritus
- Musculoskeletal pain
- Blurred vision
- Decreased libido
- Tinnitus
- Intensification of AV block
Pregnancy & Lactation
- Pregnancy Category C
- Excretion in breast milk in very small quantities
Precautions & Warnings
- Use with caution in patients with bronchospastic disease
- Controversy over withdrawing beta-blocking therapy prior to major surgery
- Masking of tachycardia occurring with hypoglycemia
- Caution in patients with peripheral vascular disease
- Caution when used with calcium channel blockers
- Use with caution in patients with impaired hepatic function
- No clinically relevant differences in the adverse event profile for pediatric patients aged 6 to 16 years
- Safety and effectiveness not established in patients <6 years of age
- No notable differences in efficacy or adverse events between older and younger patients
Use in Special Populations
- Caution in patients with impaired hepatic function
- Safety and effectiveness not established in patients <6 years of age
Overdose Effects
- Severe hypotension
- Sinus bradycardia
- Atrioventricular block
- Heart failure
- Cardiogenic shock
- Cardiac arrest
- Bronchospasm
- Impairment of consciousness
- Coma
- Nausea
- Vomiting
- Cyanosis
- Hypoglycemia
- Hyperkalemia
Storage Conditions
- Store in a cool and dry place
- Protected from light