Valporin 200 mg/5 ml (Syrup)

100 ml bottle: ৳ 80.00

Medicine Details

Category Details
Generic Sodium valproate
Company Renata limited
Also available as
Valporin cr 500 mg tablet Valporin cr 300 mg tablet Valporin cr 200 mg tablet

Indications

  • Treatment of all types of epilepsy
  • Prophylaxis of febrile convulsion
  • Prophylaxis of post-traumatic epilepsy
  • Treatment of bipolar disorder
  • Prophylaxis of migraine

Composition

  • Sodium Valproate tablet contains Sodium Valproate BP 200 mg
  • Sodium Valproate syrup contains Sodium Valproate BP 200 mg
  • Sodium Valproate controlled release 200 tablet contains Sodium Valproate BP 133.2 mg & Valproic acid BP 58 mg
  • Sodium Valproate controlled release 300 tablet contains Sodium Valproate BP 199.8 mg & Valproic acid BP 87 mg
  • Sodium Valproate controlled release 500 tablet contains Sodium Valproate BP 333 mg & Valproic acid BP 145 mg
  • Sodium Valproate injection contains Valproic Acid 500 mg

Pharmacology

  • Endowed with anti-epileptic activity
  • Mechanism may be related to increased brain levels of gamma-aminobutyric acid (GABA)

Dosage & Administration

  • Oral administration
  • Initial dosage for adults, children (over 20 kg), and children (up to 20 kg)
  • Maintenance dose for epilepsy and bipolar disorder
  • Injection for adults and children
  • Slow intravenous injection over 3-5 minutes
  • Continuous or repeated infusion

Interaction

  • Acts as a non-specific inhibitor of drug metabolism
  • Significant interactions with Phenobarbital, Phenytoin, Warfarin, Aspirin

Contraindications

  • Known hypersensitivity to the drug
  • Liver dysfunction
  • Restricted use during pregnancy and in women of childbearing potential

Side Effects

  • Anorexia, nausea, and vomiting
  • Effects on the CNS such as sedation, ataxia, and tremor
  • Rash, alopecia, and stimulation of appetite
  • Elevation of liver enzymes in plasma observed in up to 40% of patients
  • Fulminate hepatitis (rare)
  • Hepatic injury, acute pancreatitis, and hyperammonemia in children below 2 years of age and those being treated with multiple antiepileptic agents
  • Effects on hepatic function

Pregnancy & Lactation

  • Exposure to valproate in the first trimester associated with neural tube defects
  • Crosses the placenta
  • Excreted in breast milk

Precautions & Warnings

  • Monitoring of liver functions
  • No undue potential for bleeding before starting and before major surgery
  • Care in renal impairment, pregnancy, breast-feeding, and systemic lupus erythematosus
  • Valporin is partially eliminated in the urine as a ketone metabolite
  • Sudden withdrawal of therapy should be avoided

Therapeutic Class

  • Primary anti-epileptic drugs

Storage Conditions

  • Do not store above 30°C
  • Keep away from light
  • Keep out of the reach of children

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