Valporin CR 500 mg (Tablet (Controlled Release))

Unit Price: ৳ 12.00 (5 x 6: ৳ 360.00)
Strip Price: ৳ 72.00

Medicine Details

Category Details
Generic Sodium valproate
Company Renata limited
Also available as
Valporin 200 mg syrup Valporin cr 300 mg tablet Valporin cr 200 mg tablet

Indications

  • Treatment of all types of epilepsy
  • Treatment of bipolar disorder
  • Prophylaxis of migraine
  • Prophylaxis of febrile convulsion
  • Prophylaxis of post-traumatic epilepsy

Composition

  • Sodium Valproate BP 200 mg tablet
  • Sodium Valproate BP 200 mg syrup
  • Sodium Valproate BP 133.2 mg & Valproic acid BP 58 mg controlled release 200 tablet
  • Sodium Valproate BP 199.8 mg & Valproic acid BP 87 mg controlled release 300 tablet
  • Sodium Valproate BP 333 mg & Valproic acid BP 145 mg controlled release 500 tablet
  • Sodium Valproate BP eqv. to Valproic Acid 500 mg injection

Pharmacology

  • Anti-epileptic activity against a variety of seizures
  • Increase brain levels of gamma-aminobutyric acid (GABA)

Dosage & Administration

  • Oral administration for tablets and syrup
  • Initial dosage for adults and children for different conditions
  • Variation in dosage for febrile convulsion, bipolar disorder, and migraine
  • Injection dosage for adults and children
  • Different administration methods for injection

Interaction

  • Non specific inhibitor of drug metabolism
  • Significant interaction with Phenobarbital, Phenytoin, Warfarin, Aspirin

Contraindications

  • Known hypersensitivity to the drug
  • Liver dysfunction
  • Restricted use during pregnancy and in women of childbearing potential

Side Effects

  • Common side effects such as anorexia, nausea, and vomiting
  • CNS effects like sedation, ataxia, and tremor
  • Occasional effects on hepatic function
  • Rare occurrences of fulminate hepatitis, rash, alopecia, and appetite stimulation
  • Greater susceptibility in children below 2 years with medical conditions and multiple antiepileptic agents

Pregnancy & Lactation

  • Crosses the placenta
  • Associated with neural tube defects in newborns
  • Excreted in breast milk

Precautions & Warnings

  • Monitoring of liver functions before and during therapy
  • Ensuring no potential for bleeding before major surgery
  • Special care in renal impairment, pregnancy, breast-feeding, and lupus erythematosus
  • Potential for false interpretation of urine ketone test
  • Avoiding sudden withdrawal of therapy

Therapeutic Class

  • Primary anti-epileptic drugs

Storage Conditions

  • Do not store above 30°C
  • Keep away from light
  • Keep out of the reach of children

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