Fizi 10 mg (Tablet)

Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Flunarizine
Company Beacon pharmaceuticals plc
Also available as

Indications

  • Prophylaxis of classic migraine (with aura)
  • Prophylaxis of common migraine (without aura)
  • Symptomatic treatment of vestibular vertigo
  • Symptomatic treatment of motion sickness
  • Treatment of Peripheral Vascular Disease (PVD)
  • Treatment of refractory epilepsy resistant to conventional antiepileptic therapy

Pharmacology

  • Flunarizine is a selective calcium channel antagonist
  • Reduces excessive transmembrane influx of calcium
  • Prevents cellular calcium overload
  • Has antihistaminic and sedative properties

Dosage & Administration

  • Starting dose of 10 mg at night for patients less than 65 years
  • Starting dose of 5 mg daily for patients older than 65 years
  • Maintenance treatment with a decreased dose of 5 days treatment at the same daily dose with two successive medicine free days every week
  • Peripheral Vascular disease dosage: 10 mg twice daily, up to 30 mg per day if required
  • Vertigo & motion sickness dosage: 10-20 mg daily for adults, 5 mg daily for children (> 40 kg)
  • Epileptic seizure dosage: 15-20 mg daily in adults, 5-10 mg daily in children as add-on therapy

Interaction

  • Possible interaction with oral contraceptives leading to galactorrhoea
  • Hepatic enzyme inducers such as Carbamazepine and Phenytoin may increase the metabolism of Fizi

Contraindications

  • Hypersensitivity to Flunarizine
  • Contra-indicated in patients with a history of depressive illness
  • Contra-indicated in patients with pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders

Side Effects

  • Drowsiness and/or fatigue
  • Weight gain and/or increased appetite
  • Possible adverse experiences: depression, extrapyramidal symptoms, heartburn, nausea, gastralgia, insomnia, anxiety, galactorrhoea, dry mouth, muscle ache, skin rash

Pregnancy & Lactation

  • Safety in pregnancy and lactation has not been established

Precautions & Warnings

  • May lead to drowsiness, aggravated by alcohol or other central nervous system depressants
  • Caution against driving motor vehicles or performing hazardous tasks
  • Not suited for aborting a migraine attack
  • Treatment may give rise to extrapyramidal and depressive symptoms, reveal Parkinsonism especially in predisposed patients such as the elderly

Therapeutic Class

  • Miscellaneous prophylactic migraine preparations

Storage Conditions

  • Keep below 30°C temperature
  • Keep away from light & moisture
  • Keep out of the reach of children

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