Fizi 10 mg (Tablet)
Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00
Medicine Details
Category | Details |
---|---|
Generic | Flunarizine |
Company | Beacon pharmaceuticals plc |
Also available as |
Indications
- Prophylaxis of classic migraine (with aura)
- Prophylaxis of common migraine (without aura)
- Symptomatic treatment of vestibular vertigo
- Symptomatic treatment of motion sickness
- Treatment of Peripheral Vascular Disease (PVD)
- Treatment of refractory epilepsy resistant to conventional antiepileptic therapy
Pharmacology
- Flunarizine is a selective calcium channel antagonist
- Reduces excessive transmembrane influx of calcium
- Prevents cellular calcium overload
- Has antihistaminic and sedative properties
Dosage & Administration
- Starting dose of 10 mg at night for patients less than 65 years
- Starting dose of 5 mg daily for patients older than 65 years
- Maintenance treatment with a decreased dose of 5 days treatment at the same daily dose with two successive medicine free days every week
- Peripheral Vascular disease dosage: 10 mg twice daily, up to 30 mg per day if required
- Vertigo & motion sickness dosage: 10-20 mg daily for adults, 5 mg daily for children (> 40 kg)
- Epileptic seizure dosage: 15-20 mg daily in adults, 5-10 mg daily in children as add-on therapy
Interaction
- Possible interaction with oral contraceptives leading to galactorrhoea
- Hepatic enzyme inducers such as Carbamazepine and Phenytoin may increase the metabolism of Fizi
Contraindications
- Hypersensitivity to Flunarizine
- Contra-indicated in patients with a history of depressive illness
- Contra-indicated in patients with pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders
Side Effects
- Drowsiness and/or fatigue
- Weight gain and/or increased appetite
- Possible adverse experiences: depression, extrapyramidal symptoms, heartburn, nausea, gastralgia, insomnia, anxiety, galactorrhoea, dry mouth, muscle ache, skin rash
Pregnancy & Lactation
- Safety in pregnancy and lactation has not been established
Precautions & Warnings
- May lead to drowsiness, aggravated by alcohol or other central nervous system depressants
- Caution against driving motor vehicles or performing hazardous tasks
- Not suited for aborting a migraine attack
- Treatment may give rise to extrapyramidal and depressive symptoms, reveal Parkinsonism especially in predisposed patients such as the elderly
Therapeutic Class
- Miscellaneous prophylactic migraine preparations
Storage Conditions
- Keep below 30°C temperature
- Keep away from light & moisture
- Keep out of the reach of children