Dobutin 12.5 mg/ml (IV Injection)

Indications

• Treatment of hypoperfusion states
• Inotropic support
• Treatment of abnormally increased ventricular filling pressures
• Treatment of pulmonary congestion and edema

Pharmacology

• Positive inotropic effect
• Stimulation of beta-1 adrenergic receptors
• Increase in myocardial contractility
• Increase in stroke volume
• Increase in cardiac output

Dosage

• Recommended infusion rate range of 2.5 to 40 mcg/kg/min
• Adjustment of rate and duration based on patient's response
• Use of haemodynamic parameters for dosage adjustment
• Guideline for infusion rates based on concentration of Dobutamine Hydrochloride

Administration

• Continuous intravenous infusion
• Achievement of steady-state dobutamine plasma concentration within 10 minutes
• Avoidance of loading doses or bolus injections

Interaction

• Decreased potency when given with beta-adrenergic receptor antagonists
• Possible apparent effects due to alpha-adrenergic blockade
• No overt indication of interactions with other medications

Contraindications

• Hypersensitivity to Dobutamine Hydrochloride

Side Effects

• Increased heart rate and blood pressure
• Occasional premature ventricular beats
• Hypotension
• Phlebitis and local inflammatory changes
• Nausea, headache, chest pain, palpitations, and shortness of breath
• Isolated cases of thrombocytopenia
• Mild reduction in serum potassium concentration
• No adverse effects seen with infusions up to 72 hours

Pregnancy & Lactation

• Not recommended during pregnancy unless benefits outweigh risks
• Caution advised during lactation

Precautions & Warnings

• Close monitoring of heart rate, blood pressure, and infusion rate
• Electrocardiographic monitoring upon therapy initiation

Overdose Effects

• Toxicity symptoms include anorexia, nausea, vomiting, tremor, anxiety, palpitations, headache, and more
• Possible complications such as hypertension, tachyarrhythmias, myocardial ischemia, and ventricular fibrillation
• Treatment involving discontinuation, airway establishment, resuscitative measures, and monitoring
• Use of propranolol or lidocaine for severe arrhythmias
• No established benefit from forced diuresis, peritoneal dialysis, hemodialysis, or charcoal hemoperfusion

Therapeutic Class

• Inotropic-sympathomimetics

Storage Conditions

• Store between 15-30°C

Related Brands

• DOBUTamine Hameln 250 mg/50 ml (IV Injection) - siegfried-hameln-germany