Cardopa 200 mg/5 ml (IV Injection)

Indications

• For correction of haemodynamic imbalance in acute hypotension or shock
• Adjunct after open heart surgery for persistent hypotension
• Use in chronic cardiac decompensation as in congestive failure

Pharmacology

• Stimulates alpha, beta, and dopamine receptors
• Functions as a natural catecholamine
• Produces positive chronotropic and inotropic effects on the myocardium

Dosage

• Adult dose of 2 to 5 micrograms/kg/min for modest increment of heart force and renal perfusion
• Gradual increase to 20 to 50 micrograms/kg/min in seriously ill patients if needed
• Start dose of 0.5 to 2 micrograms/kg/min for refractory chronic congestive heart failure

Administration

• Administered intravenously through a suitable intravenous catheter or needle
• Controlled using an intravenous drip chamber or metering device
• Individual titration for desired haemodynamic and/or renal response

Interaction

• Potentiated by monoamine oxidase inhibitors (MAOI's)
• Antagonized by beta-adrenergic blocking agents like Propranolol
• May increase the effect of diuretic agents

Contraindications

• Hypersensitivity to dopamine or any of its ingredients
• Phaeochromocytoma, uncorrected tachyarrhythmias, or ventricular fibrillation

Side Effects

• Ectopic beats, nausea, vomiting, tachycardia
• Anginal pain, palpitations, dyspnoea, headache
• Hypotension, hypertension, vasoconstriction

Pregnancy & Lactation

• No evidence of teratogenic effects in animal studies
• Use in pregnant women if benefits outweigh potential risks to the fetus
• Not recommended for breastfeeding mothers unless expected benefits outweigh risks

Precautions & Warnings

• Should not be administered in the presence of uncorrected tachyarrhythmia or ventricular fibrillation
• Metabolized by monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT)
• Close monitoring advised in patients with impaired renal and hepatic function

Overdose Effects

• Reduce rate of administration in case of excessive blood pressure elevation
• Use of short-acting alpha-adrenergic blocking agent such as Phentolamine may be considered

Therapeutic Class

• Inotropic-sympathomimetics

Reconstitution

• Must be diluted before administration to patients
• Stable for a minimum of 24 hours after dilution in specified sterile intravenous solutions
• Do not add Cardopa solution to alkaline intravenous solutions

Storage Conditions

• Store below 25°C and protect from light

Related Brands

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