D-Dopamine 200 mg/5 ml (IV Injection)

Indications

• Recommended for correction of haemodynamic imbalance
• Used for acute hypotension or shock
• Adjunct after open heart surgery
• Chronic cardiac decompensation

Pharmacology

• Stimulates alpha, beta, and dopamine receptors
• Natural catecholamine
• Produces positive chronotropic and inotropic effects
• Does not cross the blood-brain barrier

Dosage

• Adult dosage range: 2 to 50 micrograms/kg/min
• Gradual dosage increase for seriously ill patients
• Specific dosage for chronic congestive heart failure
• Monitoring of ECG, blood pressure, and urine output

Administration

• Administered intravenously
• Controlled rate of flow in drops per minute
• Individual titration for desired haemodynamic response
• Adjustment of drug concentration to avoid unnecessary fluid expansion

Interaction

• Potentiated by monoamine oxidase inhibitors
• Antagonized by beta-adrenergic blocking agents
• Possible effects with anesthetics, ergot alkaloids, antidepressants, and diuretic agents
• Use of vasodilators in patients with heart failure

Contraindications

• Hypersensitivity to dopamine or its ingredients
• Phaeochromocytoma
• Uncorrected tachyarrhythmias or ventricular fibrillation

Side Effects

• Ectopic beats
• Nausea and vomiting
• Tachycardia and bradycardia
• Headache and hypertension

Pregnancy & Lactation

• No evidence of teratogenic effects in animal studies
• Use in pregnant women when benefits outweigh risks
• Unknown excretion in breast milk

Precautions & Warnings

• Not to be administered with uncorrected tachyarrhythmia or ventricular fibrillation
• Metabolized by monoamine oxidase and catechol-O-methyltransferase
• Close monitoring in patients with impaired renal and hepatic function
• Careful correction of hypovolaemia prior to treatment

Overdose Effects

• Excessive blood pressure elevation
• Temporary discontinuation until stabilization
• Consideration of short-acting alpha-adrenergic blocking agent

Therapeutic Class

• Inotropic-sympathomimetics

Reconstitution

• Must be diluted before administration
• Stable for a minimum of 24 hours after dilution
• Avoid adding to alkaline intravenous solutions
• Avoid mixing with alteplase or amphotericin B solution

Storage Conditions

• Store below 25°C
• Protect from light

Related Brands

• Cardopa 200 mg/5 ml (IV Injection) - aci-limited