Vcent 200 mg (Tablet)

Unit Price: ৳ 130.00 (2 x 4: ৳ 1,040.00)
Strip Price: ৳ 520.00

Medicine Details

Category Details
Generic Voriconazole
Company Pharmasia limited
Also available as

Indications

  • Treatment of invasive aspergillosis
  • Treatment of candidemia in nonneutropenic patients
  • Treatment of disseminated candidiasis in skin, abdomen, kidney, bladder wall, and wounds
  • Treatment of esophageal candidiasis
  • Treatment of serious infections caused by Scedosporium apiospermum and Fusarium species
  • Treatment for patients intolerant of or refractory to other therapy

Pharmacology

  • Triazole antifungal medication
  • Binds and inhibits ergosterol synthesis
  • Inhibits CYP450-dependent 14-alpha sterol demethylase
  • Results in depletion of ergosterol in fungal cell membrane

Dosage & Administration

  • Tablet and powder for suspension are to be taken at least one hour before or one hour following a meal
  • Different loading and maintenance dose regimens based on body weight for oral administration
  • Specific loading and maintenance dose regimens for invasive aspergillosis, candidemia, Scedosporiosis, and Fusariosis for injection
  • Dosage adjustments for specific inhibitors and inducers

Interaction

  • Adjust Vcent dosage and monitor for adverse reactions with CYP3A4, CYP2C9, and CYP2C19 inhibitors and inducers
  • Vcent may increase the concentrations and activity of drugs that are CYP3A4, CYP2C9, and CYP2C19 substrates
  • Increase maintenance oral and intravenous dosage of Vcent with co-administration of Phenytoin or Efavirenz

Contraindications

  • Known hypersensitivity to Voriconazole or any other components of this drug
  • Co-administration with terfenadine, astemizole, cisapride, pimozide, or quinidine, sirolimus due to risk of serious adverse reactions
  • Co-administration with rifampin, carbamazepine, long-acting barbiturates, efavirenz, ritonavir, rifabutin, ergot alkaloids, and St. John's Wort due to risk of loss of efficacy

Side Effects

  • Abdominal pain
  • Anemia
  • Blurred vision
  • Headache
  • Chest pain
  • Nausea
  • Diarrhea

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Use during pregnancy only if the potential benefit justifies the potential risk to the fetus

Precautions & Warnings

  • Long term exposure greater than 180 days requires careful assessment of the benefit-risk balance
  • Squamous cell carcinoma of the skin (SCC) reported in relation to long-term Vcent treatment

Use in Special Populations

  • Efficacy to children under 12 years of age is not established

Overdose Effects

  • No data found about overdose of Vcent

Therapeutic Class

  • Other antifungal preparations

Reconstitution

  • Shake the bottle well before adding water to loosen the powder
  • Add specified amount of water to the bottle and shake vigorously
  • Store reconstituted suspension between 15°C to 30°C
  • Discard suspension 14 days after reconstitution

Storage Conditions

  • Keep out of reach of children
  • Store in a dry place, below 25°C temperature, and protected from light
  • Store Vcent powder for suspension between 2°C to 8°C temperature

Related Brands