Xorest 0.5 mg (Tablet)

Indications

• Treatment of panic disorder
• Treatment of Lennox-Gastaut Syndrome
• Treatment of akinetic and myoclonic seizures
• Adjunct in the treatment of absence seizures
• Long-term use effectiveness

Pharmacology

• Anticonvulsive effects
• Sedative effects
• Muscle relaxing effects
• Anxiolytic effects
• Enhancement of GABAergic neurotransmission
• Effect on serotonin

Dosage & Administration

• Initial dose for adults with seizure disorders
• Initial dose for adults with panic disorder
• Initial dose for pediatric patients
• Dose for infants and children
• Dose for adults through oral and injection
• Maximum recommended daily dosage

Interaction

• No alteration of phenytoin, carbamazepine or phenobarbital pharmacokinetics
• Effect on the metabolism of other drugs

Contraindications

• Hypersensitivity to benzodiazepines
• Clinical or biochemical evidence of significant liver disease
• Open angle glaucoma
• Acute narrow angle glaucoma

Side Effects

• CNS depression
• Drowsiness
• Ataxia
• Behavior problems
• Abnormal eye movements
• Aphonia
• Coma
• Tremor
• Vertigo
• Depression
• Amnesia
• Hallucinations
• Insomnia
• Psychosis
• Palpitations

Pregnancy & Lactation

• Potential of producing congenital malformations
• Epidemiological evidence on teratogenic effects
• Administration during pregnancy and labor
• Passage into maternal milk
• Discontinuation of breastfeeding

Precautions & Warnings

• Increased incidence of seizures
• Concomitant use with valproic acid
• Increased pharmacologic effects in elderly patients
• Impact of renal impairment on pharmacokinetics
• Impact of hepatic impairment on pharmacokinetics

Use in Special Populations

• Increased production of saliva and bronchial secretion in infants and small children
• Greater pharmacologic effects in elderly patients
• Effect of renal impairment on pharmacokinetics
• Effect of hepatic impairment on pharmacokinetics

Overdose Effects

• Common symptoms of overdose
• Life-threatening effects
• Increased frequency of seizures
• Respiratory depressant effects
• Effects in patients with respiratory disease
• Interactions with other central nervous system depressants
• Monitoring and treatment

Therapeutic Class

• Adjunct anti-epileptic drugs
• Benzodiazepine hypnotics

Reconstitution

• Reconstitution for slow intravenous injection
• Reconstitution for intravenous infusion
• Stability of diluted mixtures
• Usage of PVC infusion bags
• Precautions for infusion using sodium bicarbonate solution
• Intramuscular injection usage

Storage Conditions

• Dry place away from light and heat
• Keep out of the reach of children

Chemical Structure

• Molecular formula
• Chemical structure image

Common Questions about Xorest 0.5 mg Tablet

• Usage as a sleeping pill
• Long-term usage
• Withdrawal symptoms
• Early symptoms of suicidal thoughts and actions
• Effect on weight
• Effect on memory
• Harmful effects of overdose
• Interactions with zolpidem
• Interactions with quetiapine
• Quick tips for usage

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