Fragmin 7500 IU/0.3 ml (SC Injection)

7500 IU pre-filled syringe: ৳ 771.00 (2 x 5: ৳ 7,710.00)

Medicine Details

Category Details
Generic Dalteparin sodium
Company Pfizer
Also available as
Fragmin 5000 iu injection

Indications

  • Prophylaxis of clotting in extracorporeal circulation in haemodialysis or haemofiltration
  • Unstable angina
  • Prophylaxis of venous thromboembolism during surgical procedures
  • Venous thromboembolism

Pharmacology

  • Acts through potentiation of the inhibition of factor Xa and thrombin by antithrombin
  • Relatively higher ability to potentiate factor Xa inhibition than to prolong aPTT

Dosage & Administration

  • Intravenous administration
  • Subcutaneous administration
  • Dosage range: 30-40 U/kg for prophylaxis of clotting in extracorporeal circulation in haemodialysis or haemofiltration
  • Dosage range: 200 U/kg/day for venous thromboembolism in pregnant and high-risk patients
  • Dosage range: 2,500 U for moderate risk surgical procedures
  • Dosage range: 120 U/kg for unstable angina

Interaction

  • Increased risk of hemorrhage with other anticoagulant/antiplatelet agents
  • Reduced anticoagulant effect with antihistamines, cardiac glycosides, tetracycline, and ascorbic acid

Contraindications

  • Hypersensitivity
  • Active major bleeding
  • Severe coagulation disorders
  • Precaution needed for lumbar puncture, sympathetic block, brain, spinal cord, eye or ear surgery, severe hypertension

Side Effects

  • Elevated serum transaminase levels
  • Allergic reactions (e.g. pruritus, rash, fever, inj site reaction, bullous eruption)
  • Pain on injection site
  • Epidural or spinal hematomas that may result in permanent paralysis
  • Severe hemorrhage
  • Thrombocytopenia

Pregnancy & Lactation

  • Pregnancy Category B
  • No demonstrated fetal risk in animal-reproduction studies
  • Adverse effects shown in animal-reproduction studies not confirmed in controlled studies in women in the 1st trimester

Precautions & Warnings

  • Increased risk of bleeding complications in certain patients
  • Increased risk of spinal or epidural hematomas in patients undergoing neuraxial anesthesia or spinal puncture
  • Hepatic and renal impairment
  • Precaution needed during pregnancy and lactation

Overdose Effects

  • Symptoms: Hemorrhagic complications
  • Management: Administer protamine sulfate by slow IV injection at a specific dose

Therapeutic Class

  • Parenteral anticoagulants

Storage Conditions

  • Store between 20-25°C

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