Cardinex 4000 Anti-Xa IU/0.4 ml (SC Injection)

Title

• Cardinex

Categories

• Medicine
• Anticoagulant

Description

• Enoxaparin Sodium BP
• Low molecular weight heparin
• Anti-Xa activity
• Pre-filled syringe
• Subcutaneous injection
• Pharmacological action
• Dosage instructions
• Injection site preparation
• Interaction with other medications
• Contraindications
• Side effects
• Pregnancy and lactation
• Storage conditions

Dosage

• 0.2 ml pre-filled syringe contains 20 mg Enoxaparin Sodium
• 0.4 ml pre-filled syringe contains 40 mg Enoxaparin Sodium
• 0.6 ml pre-filled syringe contains 60 mg Enoxaparin Sodium
• 0.8 ml pre-filled syringe contains 80 mg Enoxaparin Sodium

Indications

• Deep vein thrombosis treatment
• Unstable angina and non-Q-wave myocardial infarction treatment
• Prevention of thrombus formation during hemodialysis
• Prophylaxis of venous thromboembolic disease

Pharmacology

• High anti-Xa activity
• Low anti-lla activity
• No impact on bleeding time
• Metabolized in the liver

Composition

• Enoxaparin Sodium BP 20 mg equivalent to 2000 anti-Xa III
• Enoxaparin Sodium BP 40 mg equivalent to 4000 anti-Xa III
• Enoxaparin Sodium BP 60 mg equivalent to 6000 anti-Xa UI
• Enoxaparin Sodium BP 80 mg equivalent to 8000 anti-Xa UI

Administration

• Subcutaneous injection
• Injection site preparation and selection
• Dose selection and adjustment based on body weight
• Disposal of used syringes

Interaction

• Discontinue agents affecting hemostasis prior to therapy
• Careful clinical and laboratory monitoring

Contraindications

• Hypersensitivity to Enoxaparin Sodium or heparin
• Active major bleeding
• High risk of uncontrolled hemorrhage

Side Effects

• Haemorrhage
• Thrombocytopenia
• Elevations of serum aminotransferase
• Pain at injection sites
• Skin rash at injection sites
• Neuraxial hematomas with spinal anesthesia

Pregnancy & Lactation

• Pregnancy category B
• No evidence of crossing placental barrier
• Use during pregnancy only if clearly needed
• Unknown excretion in human milk

Precautions & Warnings

• Deep subcutaneous injection
• Do not administer by intramuscular route
• Use with caution in conditions with increased potential for bleeding
• Platelet count monitoring before and during treatment

Use in Special Populations

• No dosage adjustment in elderly patients
• Observation in renal impairment patients
• Caution in hepatically impaired patients

Overdose Effects

• Hemorrhagic complications
• Neutralization with protamine sulfate

Therapeutic Class

• Parenteral anticoagulants

Storage Conditions

• Cool and dry storage
• Protection from light and moisture
• Storage below 25°C
• Keep out of reach of children

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