Metoprol-XL 50 mg (Tablet (Extended Release))
Unit Price: ৳ 3.00 (5 x 10: ৳ 150.00)
Strip Price: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metoprolol tartrate |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- Hypertension management
- Angina pectoris management
- Cardiac arrhythmia management
- Hyperthyroidism treatment
- Pain relief
- Mortality reduction in acute myocardial infarction
Pharmacology
- Selective beta1-blocker
- Reduction of heart rate
- Reduction of blood pressure
- Interference with insulin release
- Less interference with cardiovascular response to hypoglycemia
Dosage & Administration
- Total daily dosage range: 100-400 mg
- Initial dosage for hypertension: 100 mg per day
- Initial dosage for angina: 50-100 mg two to three times daily
- Initial dosage for cardiac arrhythmia: 50-300 mg per day in divided doses
- Dosage for hyperthyroidism: 50 mg four times a day
- Oral therapy for myocardial infarction: 50 mg every 6 hours for 48 hours followed by 200 mg daily in divided doses
- Recommended starting dose for heart failure: 25-100 mg once daily
Interaction
- Additive effect with catecholamine-depleting drugs
- Increase in concentration with CYP2D6 inhibiting drugs
- Increased risk of bradycardia with digitalis glycosides
- Exacerbation of rebound hypertension with clonidine withdrawal
Contraindications
- AV block
- Uncontrolled heart failure
- Severe bradycardia
- Sick-sinus syndrome
- Cardiogenic shock
- Severe peripheral arterial disease
- Hypersensitivity to metoprolol or other B-blockers
Side Effects
- Tiredness
- Dizziness
- Depression
- Diarrhea
- Rash
- Shortness of breath
- Slow heart rate
- Mental confusion
- Headache
- Somnolence
- Nightmares
- Insomnia
- Nausea
- Dry mouth
- Gastric pain
- Constipation
- Flatulence
- Heartburn
- Pruritus
- Musculoskeletal pain
- Blurred vision
- Decreased libido
- Tinnitus
- Intensification of AV block
Pregnancy & Lactation
- Pregnancy Category C
- Excretion in breast milk
- Caution during lactation
Precautions & Warnings
- Caution in patients with bronchospastic disease
- Controversy over withdrawing beta‐blocking therapy prior to major surgery
- Masking of tachycardia during hypoglycemia
- Precipitation or aggravation of symptoms of arterial insufficiency in patients with peripheral vascular disease
- Caution in patients treated with calcium channel blockers
Use in Special Populations
- Caution in patients with impaired hepatic function
- Safety and effectiveness not established in patients <6 years
- No notable differences in efficacy or adverse events between older and younger patients
Overdose Effects
- Severe hypotension
- Sinus bradycardia
- Atrioventricular block
- Heart failure
- Cardiogenic shock
- Cardiac arrest
- Bronchospasm
- Impairment of consciousness
- Coma
- Nausea
- Vomiting
- Cyanosis
- Hypoglycemia
- Hyperkalemia
Storage Conditions
- Cool and dry place
- Protected from light