Metoprol-XL 100 mg (Tablet (Extended Release))
Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metoprolol tartrate |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- Management of hypertension
- Management of angina pectoris
- Management of cardiac arrhythmias
- Adjunct to the treatment of hyperthyroidism
- Reduction of infarct size in acute myocardial infarction
- Pain relief to decrease the need for opiate analgesics
- Reduction in mortality for patients with acute myocardial infarction
Pharmacology
- Selective beta1-blocker
- Reduction of agonistic effect on the heart of catecholamines
- Reduction in heart rate, cardiac output, cardiac contractility, and blood pressure
- Interference with insulin release and carbohydrate metabolism
- Less interference with cardiovascular response to hypoglycemia
Dosage & Administration
- Total daily dosage range for hypertension
- Total daily dosage range for angina
- Total daily dosage range for cardiac arrhythmias
- Total daily dosage range for hyperthyroidism
- Oral therapy for myocardial infarction
- Initiation dosage for extended-release tablet for hypertension
- Initiation dosage for extended-release tablet for angina pectoris
- Starting dose for heart failure
- Dosage for intravenous injection in arrhythmias
- Dosage for intravenous injection in surgery
- Dosage for intravenous injection in myocardial infarction
Interaction
- Additive effect with catecholamine‐depleting drugs
- Increase in Metoprol-XL concentration with CYP2D6 inhibiting drugs
- Increased risk of bradycardia with concomitant use of digitalis glycosides
- Exacerbation of rebound hypertension with clonidine withdrawal
Contraindications
- AV block
- Uncontrolled heart failure
- Severe bradycardia
- Sick-sinus syndrome
- Cardiogenic shock
- Severe peripheral arterial disease
- Known hypersensitivity to Metoprolol or other B-blockers
- Complicated myocardial infarction with significant bradycardia
- First-degree heart block
- Systolic hypotension
- Severe heart failure
Side Effects
- Tiredness
- Dizziness
- Depression
- Diarrhea
- Itching or rash
- Shortness of breath
- Slow heart rate
- Mental confusion
- Headache
- Somnolence
- Nightmares
- Insomnia
- Nausea
- Dry mouth
- Gastric pain
- Constipation
- Flatulence
- Digestive tract disorders
- Heartburn
- Pruritus
- Musculoskeletal pain
- Blurred vision
- Decreased libido
- Tinnitus
- Intensification of AV block
Pregnancy & Lactation
- Pregnancy Category C
- Excretion in breast milk
- Caution in nursing women
Precautions & Warnings
- Use with caution in patients with bronchospastic disease
- Controversy around withdrawing beta‐blocking therapy prior to major surgery
- Masking of tachycardia occurring with hypoglycemia
- Precipitation or aggravation of symptoms of arterial insufficiency
- Need for caution in patients treated with calcium channel blockers
Use in Special Populations
- Use with caution in patients with impaired hepatic function
- Safety and effectiveness in pediatric patients
- No notable differences in efficacy or adverse events between older and younger patients
Overdose Effects
- Severe hypotension
- Sinus bradycardia
- Atrioventricular block
- Heart failure
- Cardiogenic shock
- Cardiac arrest
- Bronchospasm
- Impairment of consciousness
- Nausea
- Vomiting
- Cyanosis
- Hypoglycemia
- Hyperkalemia
- Close monitoring of cardiovascular, respiratory, and renal function
- Treatment with sympathomimetic agents
- Use of inotropic agents
- Temporary pacing for AV block
Storage Conditions
- Store in a cool and dry place
- Protected from light