Primace 2.5 mg (Capsule)
Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ramipril |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Title
- Primace
Categories
- Medication
- Cardiology
- Hypertension
- Heart Failure
- Nephropathy
- Stroke Prevention
- Pharmacology
- ACE Inhibitor
Description
- Primace is indicated for the treatment of hypertension, congestive heart failure, post-myocardial infarction complications, and reduction of cardiovascular risk.
- It is an angiotensin-converting enzyme (ACE) inhibitor that blocks the conversion of angiotensin I to angiotensin II, leading to decreased vasopressor activity and aldosterone secretion.
- Dosage must be adjusted based on the patient's condition. Recommended dose for hypertension is 1.25-2.5 mg once daily, for heart failure after myocardial infarction it's 2.5 mg twice daily, and for prevention of major cardiovascular events it's 2.5 mg once daily for the first week, followed by 5 mg once daily.
- Primace tablets should be swallowed with sufficient liquid and must not be chewed or crushed. It can be taken before, during, or after a meal.
- Contraindications include hypersensitivity to ramipril, history of angioedema, concomitant use with sacubitril/valsartan therapy, and pregnancy.
- Side effects may include dizziness, headache, fatigue, asthenia, hypotension, cough, nausea, vomiting, rash, urticaria, and hyperkalaemia.
- It is not recommended during pregnancy or breastfeeding, and precautions should be taken in patients with impaired renal function, hyperkalaemia, hypotension, and impaired hepatic function.
- It should be used with caution in special populations such as the elderly, patients with hepatic or renal impairment, and those pretreated with diuretics.
- Overdosage may cause excessive peripheral vasodilatation, bradycardia, electrolyte disturbances, and renal failure. Management involves primary detoxification and administration of adrenergic agonists if necessary.
- Primace belongs to the therapeutic class of Angiotensin-converting enzyme (ACE) inhibitors.
- It should be stored at 30°C or below, protected from light, and kept out of the reach of children.
Dimensions
- Tablet size and shape
Color options
- N/A
Functions
- Antihypertensive
- Cardioprotective
- Vasodilator
Materials
- N/A
Technical specifications
- Long-acting
- Well-tolerated
- Dosage adjustment based on patient response
- Can be used for long-term therapy
Design elements
- N/A
Usability features
- Swallow with liquid
- Can be taken with or without food
Dosage information
- Initial dose for hypertension: 1.25-2.5 mg once daily
- Initial dose for heart failure after myocardial infarction: 2.5 mg twice daily
- Initial dose for prevention of major cardiovascular events: 2.5 mg once daily for the first week
Administration instructions
- Swallow tablets with sufficient liquid
- Do not chew or crush tablets
- Can be taken before, during, or after a meal
Interaction information
- Concomitant use with diuretics may lead to serious hypotension and hyperkalemia
- Concomitant therapy with lithium may increase serum lithium concentration
- Reduction in BP may affect the ability to drive and operate machinery
Contraindications
- Hypersensitivity to ramipril or any other ACE inhibitor
- History of angioedema
- Concomitant use with sacubitril/valsartan therapy
- Pregnancy
- Renal artery stenosis
- Hypotensive or haemodynamically unstable states
Side effects
- Dizziness
- Headache
- Fatigue
- Asthenia
- Hypotension
- Cough
- Nausea
- Vomiting
- Rash
- Urticaria
- Hyperkalaemia
Pregnancy lactation information
- Must not be taken during pregnancy
- Pregnancy must be excluded before starting treatment
- Not recommended during breastfeeding
Precautions warnings
- Use with caution in patients with impaired renal function
- Use with caution in patients with hyperkalaemia
- Use with caution in patients with hypotension
- Use with caution in patients with impaired hepatic function
Special population information
- Elderly: Consider reduced initial dose
- Hepatic impairment: Initiate treatment under close medical supervision
- Renal impairment: Consider reduced initial dose based on creatinine clearance
Overdose effects
- Excessive peripheral vasodilatation
- Bradycardia
- Electrolyte disturbances
- Renal failure
Management of overdose
- Primary detoxification by gastric lavage and administration of adsorbents
- Consider administration of adrenergic agonists if necessary
Therapeutic class
- Angiotensin-converting enzyme (ACE) inhibitors
Storage conditions
- Store at 30°C or below
- Protect from light
- Keep out of the reach of children
- Do not use after the expiry date