Avidro 0.5 mg (Tablet)

Indications

• Prophylactic treatment of vascular headache of migraine type
• Classical migraine
• Common migraine
• Cluster headache

Description

• Tricyclic compound
• Antagonizes serotonin receptor competitively
• Antihistamine properties
• Antibradykinin properties
• Weak anticholinergic properties
• Appetite-stimulating properties

Pharmacology

• Inhibits peripheral actions of serotonin and histamine
• Increases membrane permeability of cranial vessels
• Alters pain thresholds in migraines
• Attenuates signaling of serotonin in causing cranial vasoconstriction
• Inhibits peripheral actions of bradykinin
• Inhibits serotonin reuptake by blood platelets
• Affects tonicity and decreases passive distension of extracranial arteries

Dosage & Administration

• 1.5 mg daily for adults
• 1.5 mg daily for children (aged over 2 years)
• Maximum dosage of 4.5 mg daily for adults
• Up to 3 mg as a single dose for adults
• Divided doses for children
• 1 mg as a single dose at night for children

Interaction

• Enhances central effects of sedatives, hypnotics, antihistamines, and alcohol
• Antagonizes hypotensive effect of adrenergic neurone blockers

Contraindications

• Known hypersensitivity to any of its ingredients

Side Effects

• Appetite stimulating effect
• Increase in body weight
• Drowsiness

Pregnancy & Lactation

• Limited information on use in pregnancy
• No reported ill effects in pregnancy
• Potential benefit to mother justifies potential risk to the fetus
• Safety during lactation not established
• Mothers should avoid taking it when breastfeeding

Precautions & Warnings

• Urinary retention
• Renal impairment
• Drowsiness affecting driving and machinery operation
• Enhances the action of alcohol

Therapeutic Class

• Anti-histamine Preparations
• Other drugs for migraine

Storage Conditions

• Keep in a dry place away from light and heat
• Keep out of the reach of children

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