Tolosa 80 mg/4 ml (IV Infusion)
4 ml vial: ৳ 8,500.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tocilizumab |
| Company | Incepta pharmaceuticals ltd |
Indications
- Rheumatoid Arthritis (RA)
- Polyarticular Juvenile Idiopathic Arthritis (PJIA)
- Systemic Juvenile Idiopathic Arthritis (SJIA)
- COVID-19
- Cytokine Release Syndrome (CRS)
- Giant Cell Arteritis (GCA)
- Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD)
Pharmacology
- Recombinant humanized anti-human interleukin 6 (IL-6) receptor monoclonal antibody
- Binds to both soluble and membrane-bound IL-6 receptors
- Inhibits IL-6-mediated signaling
Dosage & Administration
- Intravenous infusion
- Subcutaneous injection
- Recommended dosage regimen for different conditions and patient weights
- Dosing interruption for management of laboratory abnormalities
Interaction
- Exercise caution when coadministering with CYP3A4 substrate drugs
- Effect on CYP450 enzyme activity
Contraindications
- Known hypersensitivity to Tocilizumab
Side Effects
- Common adverse reactions
- Specific adverse reactions in COVID-19 patients
Pregnancy & Lactation
- Potential fetal harm based on animal data
- Considerations for use during pregnancy and breastfeeding
Precautions & Warnings
- Serious infections
- Tuberculosis evaluation
- Gastrointestinal perforation risk
- Hepatotoxicity monitoring
- Hypersensitivity reactions
- Avoidance of live vaccines
- Absolute neutrophil count and platelet count considerations
Use in Special Populations
- Pediatric use
- Geriatric use
- Hepatic impairment
- Renal impairment
Overdose Effects
- Monitoring for adverse reactions
- Administration of appropriate symptomatic treatment for adverse reactions
Therapeutic Class
- Drugs used for Rheumatoid Arthritis
Storage Conditions
- Temperature and storage instructions