Esonix M 40 mg (MUPS Tablet)

Unit Price: ৳ 14.00 (3 x 10: ৳ 420.00)

Strip Price: ৳ 140.00

Medicine Details

Category	Details
Generic	Esomeprazole mups preparation
Company	Incepta pharmaceuticals ltd
Also available as	Esonix m 20 mg tablet

Title

Esonix M 40 mg Tablet

Description

MUPS abbreviation for Multiple-Unit Pellet System
Combines the advantages of tablets and pellet-filled capsules
Greater bioavailability
Uniform emptying of micro pellets from stomach into small intestine
Facilitates rapid dissolution of enteric coating and drug release
Lesser possibility of dose dumping
Combination of fast acting and sustained action
Uniform drug release
Once daily dosing
Better than capsules in reducing esophageal residence time
Minimizes fluctuation in plasma concentration of drug
Rapid and uniform gastric emptying
Subsequently uniform drug dissolution of pellets in the gastrointestinal tract
Facilitates consistent and controlled pharmacological action
Reduction in inter- and intra-subject variability in drug absorption
Clinical response due to high number of pellets per dosage form
Prevention and treatment of NSAID associated gastric ulcers

Composition

Esomeprazole MUPS 20 Tablet:
- Contains 133.333 mg of Esomeprazole enteric coated pellets
- Equivalent to 20 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP)
Esomeprazole MUPS 40 Tablet:
- Contains 266.67 mg of Esomeprazole enteric coated pellets
- Equivalent to 40 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP)

Indications

Gastro-esophageal Reflux Disease (GERD)
Risk reduction in NSAID associated gastric ulcer
H. pylori eradication (Triple therapy)
Zollinger-Ellison syndrome and idiopathic hypersecretion

Pharmacology

Inhibits gastric acid by blocking the hydrogen-potassium adenosine triphosphatase enzyme system

Dosage

Erosive esophagitis:
- Adult (≥18 years): 40 mg once daily for 4 weeks
- Children & adolescents (12-18 years): 40 mg once daily for 4 weeks
Maintenance of healing of erosive esophagitis:
- Adult (≥18 years): 20 mg once daily
- Children & adolescents (12-18 years): 20 mg once daily
Risk reduction in NSAID associated gastric ulcer: Adult (≥18 years): 20 mg once daily for 4-8 weeks
H. pylori eradication:
- Adult (≥18 years): 20 mg twice daily for 7 days
- Children & adolescents (12-18 years): 20 mg twice daily for 7 days
Zollinger-Ellison syndrome and idiopathic hypersecretion: Adult (≥18 years): 40-80 mg twice daily

Administration

Tablets should be swallowed whole with liquid. Can be dispersed in non-carbonated water if needed

Interaction

Extensively metabolized in the liver by CYP2C19 and CYP3A4
Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4
No clinically relevant interactions with drugs metabolized by these CYP enzymes expected
Potential interference with CYP2C19, the major metabolizing enzyme
May interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability
Combination Therapy with Clarithromycin may result in increases in the plasma levels

Contraindications

Contraindicated in patients with known hypersensitivity to any of the formulation

Side effects

Headache
Diarrhoea
Nausea
Flatulence
Abdominal pain
Constipation
Dry mouth

Precautions

Use carefully in patients with severe liver dysfunction
Slightly increases the risk of hip, wrist and spine fracture over a period of more than one year

Storage conditions

Store in a cool & dry place below 25°C, protect from light. Keep out of reach of children

Chemical structure

Molecular Formula: C17H19N3O3S

Pregnancy lactation

Manufacturer advises caution. Not known if Esomeprazole or its metabolites appear in human breast milk

Commonly asked questions

Relief for GERD, ulcers, and conditions with excessive stomach acid
Possible common side effects: headaches, diarrhea, nausea, gas, stomach pain, constipation, and dry mouth
Caution advised during pregnancy and breastfeeding
Starts working within a few hours
Consult a doctor for long-term use and potential side effects