Esonix M 20 mg (MUPS Tablet)

Unit Price: ৳ 10.00 (5 x 10: ৳ 500.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Esomeprazole mups preparation
Company Incepta pharmaceuticals ltd
Also available as
Esonix m 40 mg tablet

Indications

  • Gastro-esophageal Reflux Disease (GERD)
  • Risk reduction in NSAID associated gastric ulcer
  • H. pylori eradication (Triple therapy)
  • Zollinger-Ellison syndrome and idiopathic hypersecretion

Composition

  • Esomeprazole MUPS 20 Tablet: 133.333 mg (15%w/w) of Esomeprazole enteric coated pellets equivalent to 20 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP)
  • Esomeprazole MUPS 40 Tablet: 266.67 mg (15% w/w) of Esomeprazole enteric coated pellets equivalent to 40 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP)

Description

  • Greater bioavailability
  • Uniform emptying of micro pellets from stomach into small intestine
  • Rapid dissolution of enteric coating and drug release
  • Combination of fast acting and sustained action
  • Uniform drug release
  • Once daily dosing
  • Uniform drug absorption
  • Reduced esophageal residence time
  • Minimized fluctuation in plasma concentration of drug

Pharmacology

Inhibits gastric acid by blocking the hydrogen-potassium adenosine triphosphatase enzyme system

Dosage

  • Erosive esophagitis:
    • Adult (≥18 years): 40 mg once daily for 4 weeks
    • Children & adolescents (12-18 years): 40 mg once daily for 4 weeks
  • Maintenance of healing of erosive esophagitis:
    • Adult (≥18 years): 20 mg once daily
    • Children & adolescents (12-18 years): 20 mg once daily
  • H. pylori eradication:
    • Adult (≥18 years): 20 mg twice daily for 7 days
    • Children & adolescents (12-18 years): 20 mg twice daily for 7 days
  • Zollinger-Ellison syndrome and idiopathic hypersecretion: Adult (≥18 years): 40-80 mg twice daily
  • Children 1-11 years:
    • Erosive esophagitis: Weight <20 kg: 10 mg once daily for 8 weeks, Weight ≥20 kg: 10 mg or 20 mg once daily for 8 weeks
    • Maintenance of healing of erosive esophagitis: 10 mg once daily

Administration

Tablets should be swallowed whole with liquid; can be dispersed in non-carbonated water if required, then drink the liquid with the pellets immediately or within 30 minutes; rinse the glass with water and drink

Interaction

  • Metabolized in the liver by CYP2C19 and CYP3A4
  • May interfere with the absorption of certain drugs
  • Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4
  • No clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin

Contraindications

Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

Manufacturer advises caution regarding use during pregnancy and breastfeeding

Precautions & Warnings

  • Use carefully in patients with severe liver dysfunction and severe renal impairment
  • May slightly increase the risk of hip, wrist and spine fracture when taken over a period of more than one year

Storage Conditions

Store in a cool & dry place below 25°C, protect from light; Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-433-esomeprazole-chemical-structure-Tj2Jfp1VmPkRjNXznKqC.svg

Common Questions

  • What is Esonix M 20 mg MUPS Table used for?: Relieves heartburn, treats GERD, aids in healing erosive esophagitis, and prevents its recurrence
  • What are the side effects of Esonix M 20 mg MUPS Table?: Headaches, diarrhea, nausea, gas, stomach pain, constipation, dry mouth
  • Can I take Esonix M 20 mg MUPS Table if I am pregnant or breastfeeding?: Caution advised; consult doctor about risks and benefits

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