Exformin ER 1000 mg (Tablet (Extended Release))

Unit Price: ৳ 8.00 (5 x 10: ৳ 400.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Sun pharmaceutical bangladesh ltd
Also available as
Exformin er 500 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Particularly in overweight patients
  • Use in adults and children from 10 years of age and adolescents
  • Monotherapy or in combination with other oral antidiabetic agents or with insulin
  • Reduction of diabetic complications in overweight type 2 diabetic adult patients

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers both basal and postprandial plasma glucose
  • Different mechanism of action from sulfonylureas
  • Improves insulin sensitivity

Dosage & Administration

  • Dosage must be individualized based on effectiveness and tolerance
  • Usual starting dose for adults and children
  • Maximum recommended daily doses
  • Dosage of Metformin immediate release tablet
  • Dosage of Metformin extended release tablet
  • Dosage adjustments for renal impaired patients

Interaction

  • Limited information available about certain drug interactions
  • Enhanced absorption with Nifedipine
  • Potential interactions with cationic drugs
  • Effects on Cimetidine pharmacokinetics
  • Drugs that tend to produce hyperglycemia

Contraindications

  • Hypersensitivity to the active substance
  • Acute metabolic acidosis
  • Severe renal failure
  • Acute conditions with potential to alter renal function
  • Acute or chronic diseases causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Peripheral neuropathy in patients with vitamin B12 deficiency
  • Taste disturbance
  • Encephalopathy
  • Gastrointestinal disorders
  • Liver function test abnormalities or hepatitis
  • Skin reactions

Pregnancy & Lactation

  • Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
  • Metformin excreted into human breast milk
  • No adverse effects observed in breastfed newborns/infants
  • Breastfeeding not recommended during metformin treatment

Precautions & Warnings

  • Substantial excretion by the kidney
  • Lower vitamin B12 level
  • Increased risk of hypoglycemia when used in combination with insulin
  • Regular monitoring of renal function advised
  • Therapy should be stopped before certain clinical investigations
  • Annual estimation of Vitamin B-12 levels recommended
  • Caution during concomitant therapy with a sulphonylurea
  • Possible interaction with anticoagulants

Use in Special Populations

  • Adjustment of metformin dosage based on renal function in elderly subjects
  • No effect on growth and puberty detected
  • Special caution when prescribing to children aged between 10 and 12 years
  • Regular assessment of renal function necessary
  • Exformin ER contraindicated in patients with GFR<30 ml/min

Overdose Effects

  • Hypoglycemia not seen with certain doses
  • Lactic acidosis is a medical emergency
  • Hemodialysis as the most effective method to remove lactate and Exformin ER

Therapeutic Class

  • Biguanides

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light and moisture
  • Keep out of the reach of children

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