Exformin ER 500 mg (Tablet (Extended Release))
Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Sun pharmaceutical bangladesh ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Monotherapy for adults
- Combination therapy for adults
- Combination therapy for children and adolescents
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Starting dose for adults: 500 mg twice a day or 850 mg once a day
- Starting dose for children: 500 mg twice a day
- Maximum daily dose of 2000 mg for adults
- Maximum daily dose of 2000 mg for children
- Swallow extended-release tablet whole
Interaction
- Enhancement of absorption with Nifedipine
- Potential interaction with cationic drugs
- Minimal effect on Cimetidine pharmacokinetics
- Certain drugs leading to hyperglycemia and loss of glycemic control
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure (GFR < 30 mL/min)
- Conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Increased risk of congenital abnormalities with uncontrolled diabetes during pregnancy
- Excretion into human breast milk
- Not recommended during treatment and limited data available for breastfeeding
Precautions & Warnings
- Substantial excretion by the kidney
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia
- Regular monitoring of renal function
- Discontinuation before surgery and clinical investigations
- Caution in dehydration, serious infections, or trauma
Use in Special Populations
- Adjusted dosage for elderly based on renal function
- Confirmation of type 2 diabetes mellitus before treatment
- Caution in children aged 10-12 years
- Regular assessment of renal function
- Caution in situations where renal function may become impaired
Overdose Effects
- Lactic acidosis in overdose situations
- Hypoglycemia not seen with standard doses
- Hemodialysis for removal of lactate and drug
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light and moisture
- Keep out of the reach of children