Exformin ER 500 mg (Tablet (Extended Release))

Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Sun pharmaceutical bangladesh ltd
Also available as
Exformin er 1000 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Monotherapy for adults
  • Combination therapy for adults
  • Combination therapy for children and adolescents

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Does not produce hypoglycemia
  • Decreases hepatic glucose production
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Starting dose for adults: 500 mg twice a day or 850 mg once a day
  • Starting dose for children: 500 mg twice a day
  • Maximum daily dose of 2000 mg for adults
  • Maximum daily dose of 2000 mg for children
  • Swallow extended-release tablet whole

Interaction

  • Enhancement of absorption with Nifedipine
  • Potential interaction with cationic drugs
  • Minimal effect on Cimetidine pharmacokinetics
  • Certain drugs leading to hyperglycemia and loss of glycemic control

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure (GFR < 30 mL/min)
  • Conditions altering renal function
  • Conditions causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Taste disturbance
  • Encephalopathy
  • Gastrointestinal disorders
  • Liver function test abnormalities
  • Skin reactions

Pregnancy & Lactation

  • Increased risk of congenital abnormalities with uncontrolled diabetes during pregnancy
  • Excretion into human breast milk
  • Not recommended during treatment and limited data available for breastfeeding

Precautions & Warnings

  • Substantial excretion by the kidney
  • Lowering of vitamin B12 level
  • Increased risk of hypoglycemia
  • Regular monitoring of renal function
  • Discontinuation before surgery and clinical investigations
  • Caution in dehydration, serious infections, or trauma

Use in Special Populations

  • Adjusted dosage for elderly based on renal function
  • Confirmation of type 2 diabetes mellitus before treatment
  • Caution in children aged 10-12 years
  • Regular assessment of renal function
  • Caution in situations where renal function may become impaired

Overdose Effects

  • Lactic acidosis in overdose situations
  • Hypoglycemia not seen with standard doses
  • Hemodialysis for removal of lactate and drug

Therapeutic Class

  • Biguanides

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light and moisture
  • Keep out of the reach of children

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