Cleven 6000 Anti-Xa IU/0.6 ml (SC Injection)

0.6 ml pre-filled syringe: ৳ 576.00

Medicine Details

Category Details
Generic Enoxaparin sodium
Company Beximco pharmaceuticals ltd
Also available as
Cleven 2000 anti xa injection Cleven 4000 anti xa injection Cleven 8000 anti xa injection

Title and Description

  • Cleven
  • Parenteral anti-coagulants
  • Enoxaparin Sodium is a low molecular weight heparin with a high anti-Xa activity and low anti-lla or antithrombin activity.
  • Low molecular weight heparin with high anti-Xa activity
  • Treatment of deep vein thrombosis, with or without pulmonary embolism
  • Treatment of unstable angina and non-Q-wave myocardial infarction
  • Prevention of thrombus formation in extra corporeal circulation during hemodialysis
  • Prophylaxis of venous thromboembolic disease
  • Injection administration
  • Pre-filled syringe
  • Dosage adjustments based on kidney function
  • Recommended dose adjustments for renal impairment
  • Use in Special Populations
  • Pregnancy category B
  • Storage Conditions

Composition

  • Enoxaparin Sodium BP 20 mg equivalent to 2000 anti-Xa III
  • Enoxaparin Sodium BP 40 mg equivalent to 4000 anti-Xa III
  • Enoxaparin Sodium BP 60 mg equivalent to 6000 anti-Xa IU
  • Enoxaparin Sodium BP 80 mg equivalent to 8000 anti-Xa IU

Mode of Action

  • High anti-Xa activity
  • Low anti-lla or antithrombin activity
  • Does not increase bleeding time
  • Primarily metabolized in the liver

Dosage and Administration

  • Subcutaneously 100 anti-Xa lU/kg twice daily for 10 days
  • Subcutaneously 150 anti-Xa lU/kq once daily for 10 days
  • Subcutaneously 100 anti-Xa lU/kg twice daily for 2-8 days
  • Subcutaneously 100 anti-Xa lU/kg
  • Patients undergoing general surgery with a moderate risk of thromboembolism
  • Patients undergoing orthopedic surgery with a high risk of thromboembolism
  • Subcutaneously 4000 anti-Xa IU (0.4 ml) once daily for 7-10 days
  • Pregnancy category B

Interaction and Contraindications

  • Discontinue agents affecting hemostasis prior to Cleven therapy
  • Discontinue agents such as acetylsalicylic acid, NSAIDs, ticlopidine, clopidogrel, dextran 40, glucocorticoids, thrombolytics, and anticoagulants
  • Known hypersensitivity to Enoxaparin Sodium, heparin or other low molecular weight heparins
  • Active major bleeding
  • High risk of uncontrolled hemorrhage including recent hemorrhagic stroke

Side Effects and Overdose Effects

  • Haemorrhage (bleeding)
  • Thrombocytopenia
  • Pain, bluish marks at injection sites
  • Skin rash at injection sites
  • Neuraxial hematomas with the concurrent use of Cleven and spinal/epidural anesthesia
  • Neutralization by protamine sulfate

Pregnancy & Lactation

  • Pregnancy category B
  • No evidence of Enoxaparin Sodium crossing the placental barrier
  • Caution in nursing mothers

Precautions and Warnings

  • Caution in conditions with increased potential for bleeding
  • Platelet counts measurement before the initiation of treatment

Pediatric Uses and Overdose Effects

  • No dosage adjustment in elderly patients unless kidney function is impaired
  • No dosage adjustment recommended in patients with moderate and mild renal impairment
  • Dosage adjustments for severe renal impairment
  • Caution in hepatically impaired patients

Storage Conditions

  • Store in a cool and dry place
  • Protect from light and moisture
  • Do not store above 25°C
  • Keep out of the reach of children

Related Brands