Rivamer 3 mg (Capsule)
Unit Price: ৳ 40.00 (3 x 10: ৳ 1,200.00)
Strip Price: ৳ 400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Rivastigmine tartrate |
| Company | Sun pharmaceutical bangladesh ltd |
| Also available as |
Indications
- Symptomatic treatment of mild to moderately severe Alzheimer's dementia
- Symptomatic treatment of mild to moderately severe dementia in patients with Idiopathic Parkinson's disease
Pharmacology
- Carbamate derivative
- Structurally related to physostigmine
- Binds reversibly with and inactivates cholinesterase
- Increases concentration of acetylcholine at cholinergic synapses
- Relatively specific for brain acetylcholinesterase and butyrylcholinesterase
Dosage
- Initial dose: Rivastigmine 1.5 mg twice a day
- Dose titration: 1.5 mg, 3 mg, 4.5 mg, 6 mg twice a day
- Maintenance dose: 3 mg to 6 mg twice a day
- Re-initiation of therapy: 1.5 mg twice daily
- Rivastigmine transdermal patch: 4.6 mg/24 hours, 9.5 mg/24 hours, 13.3 mg/24 hours
Administration
Twice a day, with morning and evening meals
Interaction
- Exaggerates effects of succinylcholine-type muscle relaxants during anesthesia
- Caution with anaesthetic agents
- No concomitant use with other cholinomimetic substances
- May interfere with the activity of anticholinergic medicinal products
- No pharmacokinetic interaction with digoxin, warfarin, diazepam, or fluoxetine
Contraindications
Hypersensitivity to the active substance or other carbamate derivatives
Side Effects
- Most commonly reported adverse reactions are gastrointestinal
- Nausea (38%) and vomiting (23%)
- Female patients more susceptible than male patients to gastrointestinal adverse reactions and weight loss
Pregnancy & Lactation
Not recommended during pregnancy; excreted into milk
Precautions & Warnings
- Patients with sick sinus syndrome or conduction defects
- Cholinergic stimulation may increase gastric acid secretion
- May exacerbate urinary obstruction and seizures
- Monitor body weight
- Astma or obstructive pulmonary disease
- May worsen extrapyramidal symptoms
Use in Special Populations
- Increased exposure in moderate renal and mild to moderate hepatic impairment
- Not recommended for use in children
Overdose Effects
- Symptoms may include nausea, vomiting, diarrhea, hypertension, hallucinations
- Bradycardia and/or syncope may occur
- Conservative management recommended
- Use of antiemetics considered in case of severe nausea and vomiting
- In massive overdose, atropine can be used
Therapeutic Class
Drugs for Dementia
Storage Conditions
Store in a cool and dry place, protected from light