Ranoxen Plus 375 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 8.00 (4 x 10: ৳ 320.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Rangs pharmaceuticals ltd
Also available as
Ranoxen plus 500 mg tablet

Title

  • Naproxen & Esomeprazole Tablet

Categories

  • Pain Relief
  • Gastric Ulcer Prevention
  • NSAID Therapy
  • Arthritis Treatment

Description

  • Relieves signs and symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis
  • Decreases the risk of developing gastric ulcers in patients at risk of NSAID-associated gastric ulcers
  • Combination of an immediate release Esomeprazole Magnesium layer and an enteric-coated Naproxen core
  • Recommended dosage for adults and adolescent patients based on weight and condition
  • Should be taken at least 30 minutes before meals
  • Contraindicated during the third trimester of pregnancy
  • Not recommended during breastfeeding
  • Should be avoided in patients with moderate to severe renal impairment
  • Store at temperature below 30°C, protect from light and moisture

Dimensions

  • 12mm x 6mm x 2mm

Color options

  • White

Functions

  • Relieves pain and inflammation
  • Reduces gastric acidity
  • Inhibits prostaglandin synthesis

Materials

  • Esomeprazole Magnesium
  • Enteric-coated Naproxen
  • Tablet coating

Technical specifications

  • Contains 375mg or 500mg of naproxen and 20mg of esomeprazole per tablet
  • Immediate release esomeprazole layer followed by dissolution of naproxen in the small intestine
  • Should not be split, chewed, crushed or dissolved

Design elements

  • Enteric-coated core
  • Bi-layer tablet design

Usability features

  • Lowest effective dose recommended for shortest duration
  • Easy to swallow tablet

Interaction with medications

  • May reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
  • May interfere with the absorption of drugs where gastric pH is important

Interaction with food

  • Administration with high-fat food does not affect absorption of naproxen but prolongs time to reach peak concentration

Contraindications

  • Known hypersensitivity to any component of the tablet
  • History of asthmay urticaria or allergic reactions after taking aspirin or other NSAIDs
  • Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Side effects

  • Decreased incidence of gastrointestinal side effects from Naproxen
  • Decreased occurrence of gastric ulcers and NSAID-associated upper GI events compared to Naproxen alone
  • Potential small increased risk of arterial thrombotic events with long-term use
  • Reports of oedema, hypertension, cardiac failure, gastrointestinal adverse events, etc.

Pregnancy and lactation

  • Not recommended during the third trimester of pregnancy
  • Not recommended during breastfeeding
  • May impair female fertility

Precautions and warnings

  • Avoid use with other NSAIDs, especially cyclooxygenase-2 selective inhibitors
  • Minimize undesirable effects by using lowest effective dose for shortest duration
  • Caution in older people, patients with high age, concomitant use of anticoagulants, etc.
  • Regular surveillance for patients on long-term treatment
  • Increased risk of ulcers in older people

Special population use

  • Adjustment of dosage may be required in elderly patients
  • Not recommended for patients with moderate to severe or severe renal impairment
  • Monitor patients with hepatic impairment closely
  • Use caution when high doses are required in the elderly

Overdose effects and management

  • Symptoms of Naproxen overdose include lethargy, dizziness, abdominal discomfort, renal dysfunction, etc.
  • Symptoms of Esomeprazole overdose are transient
  • No specific antidotes
  • Symptomatic and supportive care recommended

Therapeutic class

  • Drugs for Osteoarthritis
  • Drugs for Rheumatoid Arthritis
  • NSAIDs

Storage conditions

  • Store at temperature below 30°C
  • Protect from light & moisture
  • Keep out of reach of children

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