Dexkof Plus (20 mg+10 mg+2.5 mg)/5 ml (Syrup)

Indications

• Temporarily relieves symptoms of common cold
• Temporarily relieves symptoms of hay fever
• Temporarily relieves symptoms of other upper respiratory allergies
• Relieves cough due to throat irritation
• Relieves cough due to bronchial irritation
• Relieves runny nose
• Relieves sneezing
• Relieves itching of the nose or throat
• Relieves itchy, watery eyes
• Relieves nasal congestion
• Reduces swelling of nasal passages

Pharmacology

• Mixture of antitussive, decongestant, and antihistamine agent
• Contains dextromethorphan as a non-narcotic antitussive agent
• Contains phenylephrine as a decongestant
• Contains triprolidine as a competitive histamine H1-receptor antagonist

Dosage

• Recommended dosage for adults and children 12 years of age and older: 1 teaspoonful (5 ml) every 4 hours
• Recommended dosage for children 6 to under 12 years of age: ½ teaspoonful (2.5 ml) every 4 hours
• Recommended dosage for children 2 to 6 years: To be used with caution and as advised by the physician
• Not to be used in children below 2 years old

Administration

• Can be taken with or without food
• Liquid doses should be measured carefully
• Use the measuring device that comes with this medicine

Interaction

• May interact with certain MAO inhibitors
• Caution should be exercised when taking with antihistamines, antispasmodics, beta blockers, drugs for Parkinson’s disease, guanethidine, inhaled anesthetics, methyldopa, reserpine, scopolamine, tricyclic antidepressants, anti-seizure drugs, medicine for sleep or anxiety, muscle relaxants, narcotic pain relievers, or psychiatric medicines

Contraindications

• Avoid in patients with liver disease
• Avoid in asthmatic patients
• Contraindicated in patients taking monoamine oxidase inhibitors or within 2 weeks from stopping such treatment
• Contraindicated in patients with known hypersensitivity to phenylephrine hydrochloride or dextromethorphan hydrobromide
• Contraindicated during acute attacks of asthma
• Contraindicated in patients with severe hypertension
• Contraindicated in patients with severe coronary artery disease

Side Effects

• May cause drowsiness
• May cause dottiness
• May cause constipation
• Other side effects may include GIT discomfort, transient hypertension, dry mouth, restlessness, palpitations, allergic reactions, toxic psychosis, and blood dyscrasia

Pregnancy & Lactation

• Avoid use in pregnancy and lactation

Precautions & Warnings

• May cause drowsiness
• Avoid driving or operating machinery if affected
• Avoid alcoholic drinks while on this medication
• Use with caution in patients with epilepsy, prostatic hypertrophy, glaucoma, hepatic disease, hypertension, heart disease, diabetes, hyperthyroidism, patients with stenosing peptic ulcer, pyloro-duodenal obstruction, or bladder neck obstruction
• Consult a physician if symptoms do not improve within one week or are accompanied by high fever

Overdose Effects

• Hospital admission is strongly advised in cases of overdose
• Overdose may produce respiratory depression, paranoid psychosis, delusions, hallucinations, and convulsions
• Treatment should include emptying the stomach by aspiration or gastric lavage
• Nervous stimulation and convulsions should be treated with a sedative such as diazepam intramuscularly
• Severe overdose of phenylephrine hydrochloride may produce hypertension and associated reflex bradycardia

Therapeutic Class

• Combined cough suppressants

Storage Conditions

• Keep out of the reach of children
• Store in a cool and dry place
• Protect from light

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