Clamycin 500 mg (Tablet)

Unit Price: ৳ 40.00 (3 x 4: ৳ 480.00)
Strip Price: ৳ 160.00

Medicine Details

Category Details
Generic Clarithromycin
Company Biopharma limited

Indications

  • Acute bacterial exacerbation of chronic bronchitis in adults
  • Acute maxillary sinusitis
  • Community-acquired pneumonia
  • Pharyngitis or tonsillitis
  • Uncomplicated skin and skin structure infections
  • Acute otitis media in pediatric patients
  • Treatment and prophylaxis of disseminated mycobacterial infections
  • Helicobacter pylori infection and duodenal ulcer disease in adults

Pharmacology

  • Inhibits microsomal protein synthesis in susceptible organisms by binding to the bacterial ribosome
  • Active against most Gram-positive bacteria, Chlamydia, some Gram-negative bacteria, and Mycoplasmas
  • More acid-stable than Erythromycin and has twice the activity against H. influenzae

Dosage & Administration

  • Adults:
    • Acute bacterial exacerbation of chronic bronchitis: 250-500 mg every 12 hours for 7-14 days
    • Acute maxillary sinusitis: 500 mg every 12 hours for 14 days
    • Community-acquired pneumonia: 250 mg every 12 hours for 7-14 days
    • Pharyngitis or tonsillitis: 250 mg every 12 hours for 10 days
    • Uncomplicated skin and skin structure infections: 250 mg every 12 hours for 7-14 days
  • Children: 15 mg/kg/day divided every 12 hours for 10 days; 7.5 mg/kg every 12 hours up to 500 mg every 12 hours for mycobacterial infections
  • Renal and hepatic impairment: May require decreased dosage or prolonged dosing intervals

Interaction

Contraindicated with specific medications such as HMG-CoA reductase inhibitors, gastroprokinetic agents, ergot alkaloids, antipsychotics, anti-gout agents, and certain antiarrhythmics

Contraindications

  • Known hypersensitivity to clarithromycin, erythromycin, or any macrolide antibacterial drugs
  • History of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin

Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Stomatitis
  • Glossitis
  • Headache
  • Allergic reactions including urticaria and mild skin reactions
  • Taste perversion
  • Transient central nervous system side effects like anxiety and dizziness

Pregnancy & Lactation

  • Use in neonates and children in appropriate doses
  • Breast milk from mothers receiving Clarithromycin should not be given to infants until treatment is completed
  • Not recommended in pregnant patients

Precautions & Warnings

  • Discontinue if severe acute hypersensitivity reactions occur
  • Avoid in patients with known QT prolongation or receiving drugs known to prolong the QT interval
  • Consider risks and benefits when prescribing for patients with coronary artery disease
  • Evaluate for Clostridium difficile associated diarrhea if diarrhea occurs
  • Exacerbation of myasthenia gravis reported in patients receiving Clamycin therapy

Use in Special Populations

  • Established safety and effectiveness in pediatric patients for various infections
  • Not studied in pediatric patients under 6 months of age

Overdose Effects

Ingestion of large amounts may produce gastrointestinal symptoms; prompt elimination of unabsorbed drug and supportive measures are recommended

Therapeutic Class

Macrolides

Storage Conditions

Store in a cool and dry place, protected from light & moisture; reconstituted suspension must be used within 7 days at room temperature and within 14 days when refrigerated; keep out of reach of children

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