Clamycin 500 mg (Tablet)

Unit Price: ৳ 40.00 (3 x 4: ৳ 480.00)

Strip Price: ৳ 160.00

Medicine Details

Category	Details
Generic	Clarithromycin
Company	Biopharma limited

Indications

Acute bacterial exacerbation of chronic bronchitis in adults
Acute maxillary sinusitis
Community-acquired pneumonia
Pharyngitis or tonsillitis
Uncomplicated skin and skin structure infections
Acute otitis media in pediatric patients
Treatment and prophylaxis of disseminated mycobacterial infections
Helicobacter pylori infection and duodenal ulcer disease in adults

Pharmacology

Inhibits microsomal protein synthesis in susceptible organisms by binding to the bacterial ribosome
Active against most Gram-positive bacteria, Chlamydia, some Gram-negative bacteria, and Mycoplasmas
More acid-stable than Erythromycin and has twice the activity against H. influenzae

Dosage & Administration

Adults:
- Acute bacterial exacerbation of chronic bronchitis: 250-500 mg every 12 hours for 7-14 days
- Acute maxillary sinusitis: 500 mg every 12 hours for 14 days
- Community-acquired pneumonia: 250 mg every 12 hours for 7-14 days
- Pharyngitis or tonsillitis: 250 mg every 12 hours for 10 days
- Uncomplicated skin and skin structure infections: 250 mg every 12 hours for 7-14 days
Children: 15 mg/kg/day divided every 12 hours for 10 days; 7.5 mg/kg every 12 hours up to 500 mg every 12 hours for mycobacterial infections
Renal and hepatic impairment: May require decreased dosage or prolonged dosing intervals

Interaction

Contraindicated with specific medications such as HMG-CoA reductase inhibitors, gastroprokinetic agents, ergot alkaloids, antipsychotics, anti-gout agents, and certain antiarrhythmics

Contraindications

Known hypersensitivity to clarithromycin, erythromycin, or any macrolide antibacterial drugs
History of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin

Side Effects

Nausea
Vomiting
Diarrhea
Abdominal pain
Stomatitis
Glossitis
Headache
Allergic reactions including urticaria and mild skin reactions
Taste perversion
Transient central nervous system side effects like anxiety and dizziness

Pregnancy & Lactation

Use in neonates and children in appropriate doses
Breast milk from mothers receiving Clarithromycin should not be given to infants until treatment is completed
Not recommended in pregnant patients

Precautions & Warnings

Discontinue if severe acute hypersensitivity reactions occur
Avoid in patients with known QT prolongation or receiving drugs known to prolong the QT interval
Consider risks and benefits when prescribing for patients with coronary artery disease
Evaluate for Clostridium difficile associated diarrhea if diarrhea occurs
Exacerbation of myasthenia gravis reported in patients receiving Clamycin therapy

Use in Special Populations

Established safety and effectiveness in pediatric patients for various infections
Not studied in pediatric patients under 6 months of age

Overdose Effects

Ingestion of large amounts may produce gastrointestinal symptoms; prompt elimination of unabsorbed drug and supportive measures are recommended

Therapeutic Class

Macrolides

Storage Conditions

Store in a cool and dry place, protected from light & moisture; reconstituted suspension must be used within 7 days at room temperature and within 14 days when refrigerated; keep out of reach of children