Ortho-D3 2000 IU (Tablet)
Unit Price: ৳ 2.50 (3 x 10: ৳ 75.00)
Strip Price: ৳ 25.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cholecalciferol vitamin d3 |
| Company | Biopharma limited |
| Also available as |
Indications
- Vitamin D3 deficiency
- Limited exposure to sunlight
- Diet deficient in Vitamin D3
- Healthy bones and teeth
- Preventing rickets, osteomalacia, and osteoporosis
- Preventing pre-eclampsia during pregnancy
- Immunity boost
Pharmacology
- Active form of Vitamin D3: Calcitriol
- Vitamin D receptors (VDRs) binding
- Fat-soluble with a half-life of about 50 days
- Absorption in the small intestine
- Metabolism to 25-hydroxy Vitamin D3 (Calcidiol)
- Second hydroxylation to 1,25-dihydroxy Vitamin D3 (Calcitriol)
- Absorption of calcium
- Storage in tissues such as fat and muscle
- Elimination via faeces and urine
Dosage & Administration
- Adult dosage for Vitamin D3 deficiency
- Adult dosage for prevention of Vitamin D3 deficiency
- Dosage for specific therapy for osteoporosis
- Pediatric dosage for Vitamin D3 deficiency
- Pediatric dosage for prevention of Vitamin D3 deficiency
- Dosage for film-coated tablet
- Dosage for oroflash or chewable tablets
- Dosage for syrup
- Injection dosage for prevention
- Injection dosage for Vitamin D deficiency
Interaction
- Drugs causing Vitamin D3 deficiencies
- Interference with absorption and metabolism
- Effects of Magnesium containing Antacids, Digoxin, Thiazide Diuretics, Cholestyramine, Cholistipol, Phenytoin, Phenobarbital, Orlistat, Mineral Oil, and Corticosteroids
Contraindications
- Diseases associated with hypercalcaemia
- Hypersensitivity to Vitamin D3 or similar medicines
- Evidence of Vitamin D3 toxicity
Side Effects
- Anorexia
- Lassitude
- Nausea & vomiting
- Diarrhea
- Constipation
- Weight loss
- Polyuria
- Sweating
- Headache
- Thirst
- Vertigo
- Raised concentrations of calcium and phosphate in plasma and urine
Pregnancy & Lactation
- Safe use of doses up to 4000 IU during pregnancy
- Recommended daily intake for pregnant women
- Excretion of Vitamin D3 and its metabolites in breast milk
- Overdose in infants induced by nursing mothers not observed
- Consideration of dose for additional vitamin D3 given to the mother
Precautions & Warnings
- Monitoring of plasma-calcium concentration
- High doses of Vitamin D3
- Renal impairment
- Pregnancy & lactation
- Usage with Digoxin and Thiazide Diuretics
- Liver or kidney disease
- Primary hyperthyroidism
- Lymphoma
- Tuberculosis
- Granulomatous disease
Use in Special Populations
- Safety & efficacy of Vitamin D3 in children under 12 years not established
Overdose Effects
- Hypervitaminosis D
Therapeutic Class
- Vitamin in bone formation
- Vitamin-D preparations
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children