Frenvas 40 mg (Tablet)
Unit Price: ৳ 28.00 (3 x 7: ৳ 588.00)
Strip Price: ৳ 196.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Atorvastatin calcium |
| Company | Radiant pharmaceuticals ltd |
| Also available as |
Title
- Frenvas 40 mg Tablet
Categories
- Medicine
- Pharmaceutical
Description
- Adjunct to diet to reduce elevated total cholesterol and triglycerides levels
- Selective inhibitor of HMG-CoA reductase
- Rapidly absorbed after oral administration
- Extensively metabolized to active derivatives
- Eliminated primarily in bile following hepatic and/or extra-hepatic metabolism
- Well-tolerated with frequent side effects such as constipation, flatulence, and dyspepsia
- Contraindicated in pregnancy, lactation, active liver disease, and hypersensitivity reactions
- Increased risk of myopathy with concurrent administration of certain drugs
- Dosage varies for different types of hypercholesterolemia and cardiovascular event prevention
Dimensions
Color options
Functions
- Reduces total cholesterol and LDL cholesterol levels
- Increases hepatic LDL receptors for enhanced uptake and catabolism of LDL
Materials
Technical specifications
- Molecular Formula: C33H35FN2O5
- Systemic availability of HMG-CoA reductase inhibitory activity is approximately 30%
- Mean volume of distribution is approximately 381 liters
- Approximately 70% of circulating inhibitory activity for HMG-CoA reductase is attributed to active metabolites
- Plasma elimination half-life in humans is approximately 14 hours
Design elements
Usability features
Indication
- Reduction of total cholesterol and LDL cholesterol in patients with heterozygous and homozygous familial hypercholesterolaemia
- Treatment of patients with elevated serum triglyceride levels in hypertriglyceridaemia
- Reduction of cardiac ischaemic events in patients with asymptomatic or mild to moderate symptomatic coronary artery disease
- Reduction of cholesterol and triglycerides in patients with mixed dyslipidemia
- Treatment of patients with dysbetalipoproteinaemia
- Reduction of cholesterol concentrations in patients with hypercholesterolemia associated with diabetes mellitus or renal transplantation
Dosage administration
- Adults: Usually 10 mg once daily, may be increased to max. 80 mg once daily if necessary
- Child (10-18 years): Initially 10 mg once daily, increased if necessary to max. 20 mg once daily
- Dosing range: 10 to 80 mg once daily
- Can be administered as a single dose at any time of the day, with or without food
Interactions
- Concurrent administration with cyclosporine, fibric acid derivatives, niacin, erythromycin, azole antifungals increases risk of myopathy
- Plasma concentrations of atorvastatin decreased when coadministered with antacids or colestipol and increased when coadministered with erythromycin
- Increased plasma digoxin concentrations when coadministered with digoxin
- Coadministration with oral contraceptives and warfarin requires consideration of increased AUC values and prothrombin time, respectively
Contraindications
- Hypersensitivity to any component of Frenvas
- Active liver disease or unexplained persistent elevations of serum transaminases
- History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors
Side effects
- Constipation
- Flatulence
- Dyspepsia
- Abdominal pain
- Infection
- Headache
- Back pain
- Rash
- Asthenia
- Arthralgia
- Myalgia
Pregnancy lactation
- Contraindicated during pregnancy and breastfeeding due to potential adverse effects on fetal development and unknown excretion in human milk
Precautions warnings
- Liver function tests should be performed before and during treatment
- Discontinue therapy if markedly elevated CPK levels occur or myopathy is diagnosed or suspected
- Use with caution in patients with substantial alcohol consumption or history of liver disease
Special populations
- Higher plasma concentrations in healthy elderly subjects
- Greater degree of LDL-lowering in the elderly patient population
- No clinically significant difference in LDL-C reduction between men and women
- Renal disease has no influence on plasma concentrations or LDL-C reduction
- Markedly increased plasma concentrations in patients with chronic alcoholic liver disease
Overdose effects
- Specific treatment not available for atorvastatin overdose
- Symptomatic and supportive measures instituted
- Serum CK levels should be monitored
Therapeutic class
- Other Anti-anginal & Anti-ischaemic drugs
- Statins
Storage conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
Chemical structure
- Molecular formula: C33H35FN2O5
- Chemical structure image url: https://medex.com.bd/storage/res/g-res-92-atorvastatin-calcium-chemical-structure-vKDE8RIA4syu8MLTgdLW.svg
Common questions
- What is Frenvas 40 mg Tablet?
- How should I take Frenvas 40 mg Tablet?
- What are the uses of Frenvas 40 mg Tablet?
- What are the Side Effects of Frenvas 40 mg Tablet?
- What are the instructions for storage and disposal of Frenvas 40 mg Tablet?
- Is Frenvas 40 mg Tablet used for lowering cholesterol?
- Will taking Frenvas 40 mg Tablet increase my risk of diabetes?
- For how long do I need to take Frenvas 40 mg Tablet? Is it safe for long-term use?
- Does Frenvas 40 mg Tablet cause weight loss?
- Can I stop taking Frenvas 40 mg Tablet?
- Does Frenvas 40 mg Tablet cause memory loss?
- Does Frenvas 40 mg Tablet make you tired?
- Can Frenvas 40 mg Tablet be prescribed to children?
- Is Frenvas 40 mg Tablet a blood thinner?
- Quick Tips for using Frenvas 40 mg Tablet