Savatril 24 mg+26 mg (Tablet)

Unit Price: ৳ 40.00 (1 x 10: ৳ 400.00)
Strip Price: ৳ 400.00

Medicine Details

Category Details
Generic Sacubitril valsartan
Company Drug international ltd

Indications

  • Reduction of cardiovascular death risk in chronic heart failure patients
  • Treatment of symptomatic heart failure in pediatric patients
  • Conjunction with other heart failure therapies
  • Substitute for angiotensin-converting enzyme inhibitor (ACEi) or other ARB

Pharmacology

  • Contains neprilysin inhibitor sacubitril
  • Contains angiotensin receptor blocker valsartan
  • Inhibition of neprilysin (NEP) via LBQ657
  • Blocking of angiotensin II type-1 (AT1) receptor via valsartan
  • Increased levels of peptides degraded by neprilysin
  • Inhibition of effects of angiotensin II by valsartan

Dosage & Administration

  • Recommended starting dose for adult heart failure
  • Dose titration for pediatric heart failure
  • Adjustment of doses based on patient's weight
  • Starting dose for pediatric patients less than 40 kg

Interaction

  • Dual blockade of the Renin-Angiotensin-Aldosterone System
  • Potassium-sparing Diuretics interaction
  • NSAIDs interaction
  • Lithium interaction

Contraindications

  • Hypersensitivity to any component
  • History of angioedema related to previous ACEi or ARB therapy
  • Concomitant use of ACE inhibitors
  • Concomitant use of aliskiren in patients with diabetes

Side Effects

  • Angioedema
  • Hypotension
  • Impaired renal function
  • Hyperkalemia
  • Cough
  • Dizziness

Pregnancy & Lactation

  • Safety and effectiveness in pediatric patients less than 1 year
  • Relevant pharmacokinetic differences in elderly patients
  • Dose adjustment in patients with hepatic impairment
  • Dose adjustment in patients with renal impairment

Precautions & Warnings

  • Potential of causing angioedema
  • Potential of lowering blood pressure
  • Necessity of monitoring serum creatinine
  • Need for periodic monitoring of serum potassium

Use in Special Populations

  • Safety and effectiveness in pediatric patients
  • Relevant pharmacokinetic differences in elderly patients
  • Starting dose adjustment for severe renal impairment
  • Starting dose adjustment for moderate hepatic impairment

Overdose Effects

  • Limited data available on overdosage
  • Potential hypotension as a result of overdosage
  • Symptomatic treatment in case of overdosage

Storage Conditions

  • Storage below 30°C
  • Protection from moisture
  • Keep out of the reach of children

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