Savatril 24 mg+26 mg (Tablet)
Unit Price: ৳ 40.00 (1 x 10: ৳ 400.00)
Strip Price: ৳ 400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sacubitril valsartan |
| Company | Drug international ltd |
Indications
- Reduction of cardiovascular death risk in chronic heart failure patients
- Treatment of symptomatic heart failure in pediatric patients
- Conjunction with other heart failure therapies
- Substitute for angiotensin-converting enzyme inhibitor (ACEi) or other ARB
Pharmacology
- Contains neprilysin inhibitor sacubitril
- Contains angiotensin receptor blocker valsartan
- Inhibition of neprilysin (NEP) via LBQ657
- Blocking of angiotensin II type-1 (AT1) receptor via valsartan
- Increased levels of peptides degraded by neprilysin
- Inhibition of effects of angiotensin II by valsartan
Dosage & Administration
- Recommended starting dose for adult heart failure
- Dose titration for pediatric heart failure
- Adjustment of doses based on patient's weight
- Starting dose for pediatric patients less than 40 kg
Interaction
- Dual blockade of the Renin-Angiotensin-Aldosterone System
- Potassium-sparing Diuretics interaction
- NSAIDs interaction
- Lithium interaction
Contraindications
- Hypersensitivity to any component
- History of angioedema related to previous ACEi or ARB therapy
- Concomitant use of ACE inhibitors
- Concomitant use of aliskiren in patients with diabetes
Side Effects
- Angioedema
- Hypotension
- Impaired renal function
- Hyperkalemia
- Cough
- Dizziness
Pregnancy & Lactation
- Safety and effectiveness in pediatric patients less than 1 year
- Relevant pharmacokinetic differences in elderly patients
- Dose adjustment in patients with hepatic impairment
- Dose adjustment in patients with renal impairment
Precautions & Warnings
- Potential of causing angioedema
- Potential of lowering blood pressure
- Necessity of monitoring serum creatinine
- Need for periodic monitoring of serum potassium
Use in Special Populations
- Safety and effectiveness in pediatric patients
- Relevant pharmacokinetic differences in elderly patients
- Starting dose adjustment for severe renal impairment
- Starting dose adjustment for moderate hepatic impairment
Overdose Effects
- Limited data available on overdosage
- Potential hypotension as a result of overdosage
- Symptomatic treatment in case of overdosage
Storage Conditions
- Storage below 30°C
- Protection from moisture
- Keep out of the reach of children