Delpark 1 mg (Tablet)
Unit Price: ৳ 3.00 (6 x 10: ৳ 180.00)
Strip Price: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct in the treatment of parkinsonism
- Adjuvant therapy for parkinsonism with levodopa
- Control of extrapyramidal disorders
- Use in postencephalitic, arteriosclerotic, and idiopathic parkinsonism
Description
- Exerts direct inhibitory effect on the parasympathetic nervous system
- Has relaxing effect on smooth musculature
Pharmacology
- Non-selective muscarinic acetylcholine receptor antagonist
- Higher affinity for central muscarinic receptors in cerebral cortex
- Lower affinity for peripheral muscarinic receptors
- May modify nicotinic acetylcholine receptor neurotransmission
- May lead to enhanced dopamine release in the striatum
Dosage & Administration
- Individualized dosage
- Low initial dose with gradual increase
- Different dosing for idiopathic parkinsonism, drug-induced parkinsonism, and concomitant use with levodopa
- Optimal level for total daily dose
- Dividing total daily intake into 3 or 4 doses
- Caution in children
Interaction
- Possible additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with alcohol or other CNS depressants
- Intensification of anticholinergic effects with monoamine oxidase inhibitors and tricyclic antidepressants
- Potential risk of drug-induced involuntary movements during concomitant administration with other drugs
Contraindications
- Hypersensitivity to Trihexyphenidyl
- Narrow angle glaucoma
Side Effects
- Dryness of the mouth
- Blurred vision
- Dizziness
- Nausea
- Nervousness
- Suppurative parotitis
- Skin rashes
- Dilatation of the colon
- Paralytic ileus
- Psychiatric manifestations
- Cognitive dysfunctions
- Constipation
- Drowsiness
- Urinary hesitancy or retention
- Tachycardia
- Dilation of the pupil
- Increased intraocular pressure
- Choreiform movements
- Weakness
- Vomiting
- Headache
- Exacerbation of parkinsonism with abrupt treatment withdrawal
- Neuroleptic malignant syndrome
- Occurrence of angle-closure glaucoma
- Paradoxical sinus bradycardia
- Dry skin
- Cycloplegia
- Hyperkinesia
- Psychosis
- Forgetfulness
- Weight loss
- Restlessness
- Chorea
- Sleep alterations
Pregnancy & Lactation
- Use only if clearly needed during pregnancy
- Caution in nursing women due to potential suppression of lactation
Precautions & Warnings
- Gonioscope evaluation prior to therapy
- Monitoring of intraocular pressures
- Consideration of narrow angle glaucoma if blurring of vision occurs
- Administration with caution in hot weather
- Potential occurrence of anhidrosis and hyperthermia
- Potential fatalities associated with overdosages
- Monitoring for symptoms of Neuroleptic Malignant Syndrome
Overdose Effects
- Central symptoms of atropine intoxication
- Neuropsychiatric signs
- Treatment involving symptomatic and supportive therapy
- Gastric lavage and absorption limitation methods
- Possible administration of diazepam or short-acting barbiturate
- Contra-indication of phenothiazines
- Necessity of respiratory support, fluid volume replacement, and acid-balance maintenance
- Unknown dialyzability
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Temperature not exceeding 30°C
- Dry place
- Protection from light