Olpres 20 mg (Tablet)

Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Olmesartan medoxomil
Company Ziska pharmaceuticals ltd
Also available as
Olpres 10 mg tablet Olpres 40 mg tablet

Title

  • Olpres 20 mg Tablet

Categories

  • Medicine
  • Pharmaceutical

Description

  • Olpres is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.
  • Angiotensin-ll receptor blocker
  • Olpres 20 mg Tablet is Angiotensin II receptor blocker which is used to treat high blood pressure.

Dosage & Administration

  • Dosage must be individualized.
  • The usual recommended starting dose of Olmesartan is 20 mg once daily when used as monotherapy in patients who are not volume-contracted.
  • Twice-daily dosing offers no advantage over the same total dose given once daily.

Pharmacology

  • Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin converting enzyme (ACE, Kininase II).
  • Olmesartan blocks the vasoconstrictor effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT 1 receptor in vascular smooth muscle.
  • Olmesartan has more than a 12,500-fold greater affinity for the AT 1 receptor than for the AT 2 receptor.

Interaction

  • No significant drug interactions were reported in studies in which Olpres was co-administered with digoxin or warfarin in healthy volunteers.
  • Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) including selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) in patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, co-administration of NSAIDs, including selective COX-2 inhibitors, with angiotensin II receptor antagonists, including Olpres, may result in deterioration of renal function.

Contraindications

  • Olmesartan is contraindicated in patients who are hypersensitive to any component of this product.

Side Effects

  • The overall frequency of adverse reactions was not dose related.
  • The rate of withdrawals due to adverse reactions in all trials of hypertensive patients was 2.4% of patients treated with Olpres and 2.7% of control patients.

Pregnancy & Lactation

  • When pregnancy is detected, discontinue this product as soon as possible.
  • It is not known whether Olmesartan is excreted in human milk, but Olmesartan is secreted at low concentration in the milk of lactating rats.

Precautions & Warnings

  • Changes in renal function may be anticipated in susceptible individuals treated with Olpres.

Overdose Effects

  • There is no experience of overdose with Olpres.
  • Clinically significant hypotension due to an overdose of Olpres requires the active support of the cardiovascular system.

Therapeutic Class

  • Angiotensin-ll receptor blocker

Storage Conditions

  • Store in cool & dry place below 30°C, protect from light & moisture.
  • Keep out of the reach of children.

Chemical Structure

  • Molecular Formula: C29H30N6O6

Uses

  • Olpres 20 mg Tablet is Angiotensin II receptor blocker which is used to treat high blood pressure.

Improvement Time

  • In most cases, the average time taken by Olpres 20 mg Tablet to reach its peak effect is around 1 day to 1 week.

Frequency

  • Olpres 20 mg Tablet is generally used once or twice a day.

Storage Instructions

  • It should be stored at room temperature, away from heat and direct light.

Quick Tips

  • Take Olpres 20 mg Tablet at the same time every day to help you remember to take it.
  • Olpres 20 mg Tablet can make you feel dizzy for the first few days.
  • Your doctor may get regular tests done to monitor the level of urea, creatinine, and potassium in your blood.

Precautions

  • Avoid taking anti-inflammatory medicines such as ibuprofen along with this medicine without consulting your doctor.

Disposal Instructions

  • Keep it away from the reach of children.

Dosage Individualization

  • Dosage must be individualized.

Starting Dose

  • The usual recommended starting dose of Olmesartan is 20 mg once daily when used as monotherapy in patients who are not volume-contracted.

Maximum Dose

  • For patients requiring further reduction in blood pressure after 2 weeks of therapy, the dose of Olmesartan may be increased to 40 mg.

Elderly Patients

  • No initial dosage adjustment is recommended for elderly patients.

Renal Impairment

  • No initial dosage adjustment is recommended for patients with moderate to marked renal impairment.

Hepatic Dysfunction

  • No initial dosage adjustment is recommended for patients with moderate to marked hepatic dysfunction.

Paediatric Use

  • Safety and effectiveness in paediatric patients have not been established.

Bioavailability

  • The bioavailability of olmesartan was not significantly altered by the co-administration of antacids.

Metabolism

  • Olpres is not metabolized by the cytochrome P450 system and has no effects on P450 enzymes.

Renin-Angiotensin-Aldosterone System

  • As a consequence of inhibiting the renin-angiotensin-aldosterone system, changes in renal function may be anticipated in susceptible individuals treated with Olpres.

Overdose Management

  • If intake is recent, gastric lavage or induction of emesis may be considered.

Hypotension Effects

  • The most likely effects of Olpres overdosage are hypotension and tachycardia.

Supportive Measures

  • Clinically significant hypotension due to an overdose of Olpres requires the active support of the cardiovascular system.

Gastric Lavage

  • If intake is recent, gastric lavage or induction of emesis may be considered.

Hypersensitivity

  • Olmesartan is contraindicated in patients who are hypersensitive to any component of this product.

Adverse Reactions

  • Treatment with Olpres was well tolerated, with an incidence of adverse reactions similar to placebo.

Oliguria

  • Treatment with angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists has been associated with oliguria in susceptible individuals.

Renal Function

  • Inhibiting the renin-angiotensin-aldosterone system may lead to changes in renal function.

Tachycardia

  • The most likely effects of Olpres overdosage are hypotension and tachycardia.

Bradycardia

  • Bradycardia could be encountered if parasympathetic (vagal) stimulation occurred.

Active Ingredient

  • Olmesartan medoxomil

Brand Name

  • Olpres 20 mg Tablet

Dizziness

  • The incidence of dizziness was higher in patients treated with Olpres compared to placebo.

Adverse Reaction Rate

  • The overall frequency of adverse reactions was not dose related.

Gastric Upset

  • If taken on an empty stomach, it might upset the stomach.

Renal Impairment Monitoring

  • Monitor renal function periodically in patients receiving Olpres and NSAID therapy.

Plasma Renin Activity

  • Blockade of the angiotensin II receptor inhibits the negative regulatory feedback of angiotensin II on renin secretion.

Maintenance Dose

  • Doses above 40 mg do not appear to have a greater effect.

Renal Reabsorption

  • Angiotensin II has effects that include renal reabsorption of sodium.

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