Olpres HZ 40 mg+12.5 mg (Tablet)

Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)

Strip Price: ৳ 150.00

Medicine Details

Category	Details
Generic	Olmesartan medoxomil hydrochlorothiazide
Company	Ziska pharmaceuticals ltd
Also available as	Olpres hz 20 mg tablet

Indications

Treatment of hypertension

Pharmacology

Olmesartan blocks vasoconstrictor effects of angiotensin-II
Hydrochlorothiazide affects renal tubular mechanisms
Effectively reduces plasma volume

Dosage & Administration

Starting dose: 20/12.5 mg once daily
Individualized dosing based on response

Interaction

Olmesartan:
- No significant drug interactions reported
Hydrochlorothiazide:
- Potential interactions with alcohol, barbiturates, narcotics
- May require dosage adjustment with antidiabetic drugs

Contraindications

Hypersensitivity to any component
Anuria or hypersensitivity to sulfonamide-derived drugs

Side Effects

Nausea
Headache
Dizziness
Hyperuricemia
Upper respiratory tract infection
Urinary tract infection

Pregnancy & Lactation

Safety and effectiveness not established

Precautions & Warnings

Periodic determination of serum electrolytes
Monitor for hyperuricemia
Caution in impaired renal function

Use in Special Populations

Renal Impairment Patients:
- Usual therapy regimen may be followed with creatinine clearance >30 ml/min
- Loop diuretics preferred for more severe impairment
Hepatic Impairment Patients:
- No dosage adjustment necessary
Paediatric use:
- Safety and effectiveness not established
Geriatric use:
- Dose selection should be cautious

Overdose Effects

Olmesartan: hypotension and tachycardia likely manifestations
Supportive treatment should be instituted
Hydrochlorothiazide: signs and symptoms include electrolyte depletion

Therapeutic Class

Combined antihypertensive preparations

Storage Conditions

Store in cool, dry place
Protect from light and moisture
Keep out of reach of children

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