Olpres HZ 40 mg+12.5 mg (Tablet)
Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Olmesartan medoxomil hydrochlorothiazide |
| Company | Ziska pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of hypertension
Pharmacology
- Olmesartan blocks vasoconstrictor effects of angiotensin-II
- Hydrochlorothiazide affects renal tubular mechanisms
- Effectively reduces plasma volume
Dosage & Administration
- Starting dose: 20/12.5 mg once daily
- Individualized dosing based on response
Interaction
- Olmesartan:
- No significant drug interactions reported
- Hydrochlorothiazide:
- Potential interactions with alcohol, barbiturates, narcotics
- May require dosage adjustment with antidiabetic drugs
Contraindications
- Hypersensitivity to any component
- Anuria or hypersensitivity to sulfonamide-derived drugs
Side Effects
- Nausea
- Headache
- Dizziness
- Hyperuricemia
- Upper respiratory tract infection
- Urinary tract infection
Pregnancy & Lactation
- Safety and effectiveness not established
Precautions & Warnings
- Periodic determination of serum electrolytes
- Monitor for hyperuricemia
- Caution in impaired renal function
Use in Special Populations
- Renal Impairment Patients:
- Usual therapy regimen may be followed with creatinine clearance >30 ml/min
- Loop diuretics preferred for more severe impairment
- Hepatic Impairment Patients:
- No dosage adjustment necessary
- Paediatric use:
- Safety and effectiveness not established
- Geriatric use:
- Dose selection should be cautious
Overdose Effects
- Olmesartan: hypotension and tachycardia likely manifestations
- Supportive treatment should be instituted
- Hydrochlorothiazide: signs and symptoms include electrolyte depletion
Therapeutic Class
- Combined antihypertensive preparations
Storage Conditions
- Store in cool, dry place
- Protect from light and moisture
- Keep out of reach of children