Vefend 200 mg (Tablet)

Unit Price: ৳ 110.00 (2 x 4: ৳ 880.00)
Strip Price: ৳ 440.00

Medicine Details

Category Details
Generic Voriconazole
Company Acme laboratories ltd
Also available as

Indications

  • Treatment of invasive aspergillosis
  • Treatment of candidemia and disseminated candidiasis
  • Treatment of esophageal candidiasis
  • Treatment of serious infections caused by specific fungal species incl. Scedosporium apiospermum and Fusarium Solani
  • Intolerance or refractory to other therapy for fungal infections

Pharmacology

  • Voriconazole is a triazole antifungal medication
  • Inhibits ergosterol synthesis
  • Binds and inhibits CYP450-dependent 14-alpha sterol demethylase
  • Results in depletion of ergosterol in fungal cell membrane

Dosage & Administration

  • Oral and Intravenous dosage recommendations based on body weight
  • Loading dose 400mg or 10ml every 12 hours for adults at or over 40kg
  • Maintenance dose 200mg or 5ml twice daily for adults at or over 40kg
  • Specific dosage regimen for patients below 40kg body weight
  • Different dosage regimen for invasive aspergillosis, candidemia, Scedosporiosis, and Fusariosis

Interaction

  • Vefend dosage adjustment with CYP3A4, CYP2C9, and CYP2C19 inhibitors and inducers
  • Possible increase in concentrations and activity of CYP3A4, CYP2C9, and CYP2C19 substrate drugs
  • Increased maintenance oral and intravenous dosage with co-administration of Phenytoin or Efavirenz

Contraindications

  • Hypersensitivity to Voriconazole or any other components
  • Co-administration precautions with specific drugs due to risk of serious adverse reactions or loss of efficacy

Side Effects

  • Common side effects include abdominal pain, anemia, blurred vision, headache, chest pain, nausea, and diarrhea

Pregnancy & Lactation

  • Insufficient well-controlled studies in pregnant women
  • Use during pregnancy only if potential benefit justifies potential risk to the fetus

Precautions & Warnings

  • Long-term exposure assessment required for treatments exceeding 180 days
  • Reports relating long-term treatment to squamous cell carcinoma of the skin (SCC)

Use in Special Populations

  • Efficacy not established in children under 12 years of age

Overdose Effects

  • No specific data available for Vefend overdose

Therapeutic Class

  • Belongs to the therapeutic class of other antifungal preparations

Reconstitution

  • Specific instructions for reconstituting the suspension
  • Storage conditions and shelf life of reconstituted suspension

Storage Conditions

  • Storage instructions for Vefend powder for suspension
  • Specific temperature and light protection requirements

Related Brands