Sugamet XR 500 mg (Tablet (Extended Release))
Unit Price: ৳ 6.00 (6 x 10: ৳ 360.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus in adults
- Treatment of type 2 diabetes mellitus in children and adolescents
- May be used as monotherapy
- May be used in combination with other oral antidiabetic agents
- May be used in combination with insulin
- Reduction of diabetic complications in overweight patients
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers both basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Dosage increases in increments
- Usual starting dose for adults
- Usual starting dose for children
- Dosage for renal impaired patients
- Instructions for swallowing extended release tablet whole
Interaction
- No information available for Sugamet XR and Furosemide interaction
- Nifedipine enhances absorption of Sugamet XR
- Minimal effects of Sugamet XR on Nifedipine
- Potential interaction with cationic drugs
- No effect on Cimetidine pharmacokinetics
- Drugs that may produce hyperglycemia
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities or hepatitis
- Skin reactions
Pregnancy & Lactation
- Uncontrolled diabetes during pregnancy associated with increased risk of congenital abnormalities and perinatal mortality
- Recommendation to use insulin during pregnancy
- Excretion of Metformin into human breast milk
- No adverse effects observed in breastfed newborns/infants
- Breastfeeding not recommended during Metformin treatment
Precautions & Warnings
- Substantial excretion of Sugamet XR by the kidney
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia
- Regular monitoring of renal function
- Treatment cessation before surgery and clinical investigations
- Annual estimation of Vitamin B-12 levels
- Monitoring blood glucose during combined therapy
- Possible interaction with Cimetidine and anticoagulants
Use in Special Populations
- Adjustment of metformin dosage based on renal function in the elderly
- No effect of metformin on growth and puberty detected during controlled clinical studies
- Caution in prescribing to children aged between 10 and 12 years
- Recommendation for regular assessment of renal function
- Special caution in situations where renal function may become impaired
Overdose Effects
- Hypoglycemia not seen with Sugamet XR doses up to 85 gm
- Lactic acidosis occurred in overdose circumstances
- Hemodialysis for removal of lactate and Sugamet XR
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children