Enoparin 4000 Anti-Xa IU/0.4 ml (SC Injection)

0.4 ml pre-filled syringe: ৳ 450.00

Medicine Details

Category Details
Generic Enoxaparin sodium
Company Popular pharmaceuticals ltd
Also available as
Enoparin 6000 anti xa injection Enoparin 8000 anti xa injection

Indications

  • Treatment of deep vein thrombosis
  • Treatment of unstable angina and non-Q-wave myocardial infarction
  • Prevention of thrombus formation in the extra-corporal circulation during hemodialysis
  • Prophylaxis of venous thromboembolic disease in patients bedridden due to acute illness
  • Prophylaxis of venous thromboembolic disease in surgical patients

Composition

  • 0.2 ml pre-filled syringe contains Enoxaparin Sodium BP 20 mg equivalent to 2000 anti-Xa III
  • 0.4 ml pre-filled syringe contains Enoxaparin Sodium BP 40 mg equivalent to 4000 anti-Xa III
  • 0.6 ml pre-filled syringe contains Enoxaparin Sodium BP 60 mg equivalent to 6000 anti-Xa IU
  • 0.8 ml pre-filled syringe contains Enoxaparin Sodium BP 80 mg equivalent to 8000 anti-Xa IU

Pharmacology

  • Low molecular weight heparin with high anti-Xa activity
  • Low anti-lla or antithrombin activity
  • Metabolized in the liver

Dosage

  • Subcutaneously 100 anti-Xa lU/kg twice daily for 10 days
  • Subcutaneously 150 anti-Xa lU/kq once daily for 10 days
  • Subcutaneously 100 anti-Xa lU/kg for prevention of thrombus formation in extra corporeal circulation during hemodialysis
  • Subcutaneously 2000 anti-Xa IU (0.2 ml) or 4000 anti-Xa IU (0.4 ml) once daily for 7 to 10 days (general surgery)
  • Subcutaneously 4000 anti-Xa IU (0.4 ml) once daily for 7 to 10 days (orthopedic surgery)
  • Subcutaneously 4000 anti-Xa IU (0.4 ml) once daily for 6- 14 days (medical patients)

Administration

  • Instructions on self-injection
  • Dose selection and preparation
  • Injecting process
  • Disposal of used syringe

Interaction

  • Discontinuation of agents affecting hemostasis prior to therapy
  • Careful clinical and laboratory monitoring for indicated combination therapy

Contraindications

  • Hypersensitivity to Enoxaparin Sodium
  • Active major bleeding
  • High risk of uncontrolled hemorrhage including recent hemorrhagic stroke

Side Effects

  • Haemorrhage (bleeding)
  • Thrombocytopenia
  • Elevations of serum aminotransferase
  • Pain, bluish marks, skin rash at injection sites
  • Cases of neuraxial hematomas with spinal/epidural anesthesia or spinal puncture

Pregnancy & Lactation

  • Pregnancy category B
  • No evidence of crossing the placental barrier
  • Caution required during pregnancy
  • Potential adverse reactions in nursing infants

Precautions & Warnings

  • Deep subcutaneous route for administration
  • Caution in conditions with increased potential for bleeding
  • Measurement of platelet counts before and during treatment

Use in Special Populations

  • No dosage adjustment in elderly patients
  • Caution required in renal impairment
  • Caution required in hepatic impairment

Overdose Effects

  • Accidental overdosage may lead to hemorrhagic complications
  • Neutralization by slow i.v. injection of protamine sulfate

Therapeutic Class

  • Parenteral anti-coagulants

Storage Conditions

  • Store in a cool and dry place
  • Protect from light and moisture
  • Do not store above 25°C

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