Sugamet XR 1000 mg (Tablet (Extended Release))

Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company General pharmaceuticals ltd
Also available as
Sugamet 500 mg tablet Sugamet 850 mg tablet Sugamet xr 500 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Management of diabetes in overweight patients
  • Monotherapy for adults
  • Combination therapy for adults
  • Combination therapy for children and adolescents

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Different mechanism of action from sulfonylureas
  • Does not produce hypoglycemia
  • Decreases hepatic glucose production
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Maximum recommended daily doses
  • Dosage adjustments for adults and children
  • Instructions for immediate release tablet
  • Instructions for extended release tablet
  • Considerations for renal impaired patients
  • Dose adjustments for renal function

Interaction

  • No information available for Sugamet XR and Furosemide interaction
  • Enhancement of Nifedipine absorption
  • Potential interaction with cationic drugs
  • Minimal effects on Cimetidine pharmacokinetics
  • Drugs that may produce hyperglycemia

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Conditions altering renal function
  • Conditions causing tissue hypoxia
  • Hepatic insufficiency
  • Acute alcohol intoxication

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Peripheral neuropathy
  • Taste disturbance
  • Encephalopathy
  • Gastrointestinal disorders
  • Liver function test abnormalities
  • Skin reactions

Pregnancy & Lactation

  • Risk of congenital abnormalities
  • Increased risk of perinatal mortality
  • Use of insulin during pregnancy
  • Excretion of metformin in breast milk
  • No adverse effects observed in breastfed newborns/infants

Precautions & Warnings

  • Substantial excretion by the kidney
  • Lowering of vitamin B12 level
  • Increased risk of hypoglycemia
  • Need for regular monitoring of renal function
  • Recommendations for surgical procedures
  • Dehydration precautions
  • Annual estimation of Vitamin B-12 levels
  • Blood glucose monitoring during combined therapy
  • Reduced renal clearance during cimetidine therapy
  • Possibility of anticoagulant interaction

Use in Special Populations

  • Adjustment of dosage based on renal function in elderly subjects
  • No effect on growth and puberty detected during controlled studies
  • Recommendations for children aged 10-12 years
  • Regular assessment of renal function
  • Caution with starting therapy affecting renal function
  • Contradictions based on GFR levels

Overdose Effects

  • Hypoglycemia not seen with Sugamet XR doses up to 85 gm
  • Occurrence of lactic acidosis
  • Treatment with hemodialysis

Therapeutic Class

  • Biguanides

Storage Conditions

  • Keep below 30°C temperature
  • Protection from light and moisture
  • Keep out of the reach of children

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