Sugamet XR 1000 mg (Tablet (Extended Release))
Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management of diabetes in overweight patients
- Monotherapy for adults
- Combination therapy for adults
- Combination therapy for children and adolescents
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Dosage adjustments for adults and children
- Instructions for immediate release tablet
- Instructions for extended release tablet
- Considerations for renal impaired patients
- Dose adjustments for renal function
Interaction
- No information available for Sugamet XR and Furosemide interaction
- Enhancement of Nifedipine absorption
- Potential interaction with cationic drugs
- Minimal effects on Cimetidine pharmacokinetics
- Drugs that may produce hyperglycemia
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal function
- Conditions causing tissue hypoxia
- Hepatic insufficiency
- Acute alcohol intoxication
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Risk of congenital abnormalities
- Increased risk of perinatal mortality
- Use of insulin during pregnancy
- Excretion of metformin in breast milk
- No adverse effects observed in breastfed newborns/infants
Precautions & Warnings
- Substantial excretion by the kidney
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia
- Need for regular monitoring of renal function
- Recommendations for surgical procedures
- Dehydration precautions
- Annual estimation of Vitamin B-12 levels
- Blood glucose monitoring during combined therapy
- Reduced renal clearance during cimetidine therapy
- Possibility of anticoagulant interaction
Use in Special Populations
- Adjustment of dosage based on renal function in elderly subjects
- No effect on growth and puberty detected during controlled studies
- Recommendations for children aged 10-12 years
- Regular assessment of renal function
- Caution with starting therapy affecting renal function
- Contradictions based on GFR levels
Overdose Effects
- Hypoglycemia not seen with Sugamet XR doses up to 85 gm
- Occurrence of lactic acidosis
- Treatment with hemodialysis
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protection from light and moisture
- Keep out of the reach of children