Enoparin 6000 Anti-Xa IU/0.6 ml (SC Injection)

0.6 ml pre-filled syringe: ৳ 500.00

Medicine Details

Category Details
Generic Enoxaparin sodium
Company Popular pharmaceuticals ltd
Also available as
Enoparin 4000 anti xa injection Enoparin 8000 anti xa injection

Indications

  • Treatment of deep vein thrombosis
  • Treatment of unstable angina and non-Q-wave myocardial infarction
  • Prevention of thrombus formation in extra-corporeal circulation during hemodialysis
  • Prophylaxis of venous thromboembolic disease in orthopedic or general surgery patients
  • Prophylaxis of venous thromboembolic disease in bedridden medical patients

Composition

  • Enoxaparin Sodium BP 20 mg equivalent to 2000 anti-Xa III in 0.2 ml pre-filled syringe
  • Enoxaparin Sodium BP 40 mg equivalent to 4000 anti-Xa III in 0.4 ml pre-filled syringe
  • Enoxaparin Sodium BP 60 mg equivalent to 6000 anti-Xa IU in 0.6 ml pre-filled syringe
  • Enoxaparin Sodium BP 80 mg equivalent to 8000 anti-Xa IU in 0.8 ml pre-filled syringe

Pharmacology

  • Low molecular weight heparin with high anti-Xa activity
  • Does not increase bleeding time at required doses
  • Primarily metabolised in the liver

Dosage

  • Subcutaneously administered for deep vein thrombosis
  • Oral anticoagulant therapy should be initiated when appropriate
  • Subcutaneously administered for unstable angina and non-Q-wave myocardial infarction, concurrently with aspirin
  • Recommended dose for prevention of thrombus formation in extra-corporeal circulation during hemodialysis
  • Doses for prophylaxis of venous thromboembolic disease in surgical and medical patients

Administration

  • Instructions for injecting yourself with Enoxaparin Sodium Syringes
  • Guidance on preparing the injection site
  • Selecting the correct dose
  • Proper technique for injecting the medication
  • Post-injection care and disposal of used syringe

Interaction

  • Recommendation to discontinue agents affecting hemostasis prior to Enoparin therapy
  • List of medications to be discontinued or used with careful monitoring during Enoparin therapy

Contraindications

  • Known hypersensitivity to Enoxaparin Sodium, heparin or other low molecular weight heparins
  • Active major bleeding
  • Conditions with high risk of uncontrolled hemorrhage

Side Effects

  • Haemorrhage (bleeding)
  • Thrombocytopenia
  • Elevations of serum aminotransferase
  • Skin reactions at injection sites
  • Cases of neuraxial hematomas with spinal anesthesia or puncture

Pregnancy & Lactation

  • Pregnancy category B
  • No evidence of Enoxaparin Sodium crossing the placental barrier in humans
  • Recommendation for use in pregnancy only if clearly needed
  • Unknown excretion of Enoxaparin in human milk
  • Advice to consider discontinuing nursing or Enoxaparin, weighing the benefits to the mother and nursing infant

Precautions & Warnings

  • Administration route cautions
  • Use with caution in conditions with increased potential for bleeding
  • Recommendation for platelet counts measurement before and during treatment

Use in Special Populations

  • No dosage adjustment in elderly patients, unless kidney function is impaired
  • Observation for signs and symptoms of bleeding in patients with renal impairment
  • Caution in hepatically impaired patients

Overdose Effects

  • Potential hemorrhagic complications from accidental overdosage
  • Neutralization with slow i.v. injection of protamine sulfate
  • Dosage of protamine sulfate equal to the dose of Enoxaparin injected

Therapeutic Class

  • Parenteral anti-coagulants

Storage Conditions

  • Cool and dry storage
  • Protection from light and moisture
  • Storage below 25°C
  • Keep out of reach of children

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