Metflu 0.5 mg+10 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Flupentixol melitracen |
| Company | Mst pharma |
Indications
- Anxiety
- Depression
- Apathy
- Psychogenic depression
- Depressive neurosses
- Masked depression
- Psychosomatic affections accompanied by anxiety and apathy
- Menopausal depressions
- Dysphoria and depression in alcoholics and drug addicts
Pharmacology
Consists of two well known and well proven compounds: flupentixol and melitracen. Flupentixol is a neuroleptic with anxiolytic and antidepressant properties. Melitracen is a bipolar thymoleptic with activating properties. In combination, the compounds render a preparation with antidepressant, anxiolytic and activating properties. Maximal serum concentration is reached in about 4 hours after oral administration. The biological half-life of flupentixol is about 35 hours and that of melitracen is about 19 hours.
Dosage & Administration
- Adults: Usually 2 tablets orally daily in the morning and noon. In severe cases, the morning dose may be increased to 2 tablets.
- Elderly patients: 1 tablet in the morning.
- Maintenance dose: Usually 1 tablet orally in the morning. In cases of insomnia or severe restlessness, additional treatment with a sedative in the acute phase is recommended.
Interaction
May enhance the response to alcohol, barbiturates and other CNS depressants. Simultaneous administration of MAO-inhibitors may cause hypertensive crises. Neuroleptics and thymoleptics reduce the antihypertensive effect of guanethidine and similar acting compounds, and thymoleptics enhance the effects of adrenaline and noradrenaline.
Contraindications
- The immediate recovery phase after myocardial infarction
- Defects in bundle-branch conduction
- Untreated narrow-angle glaucoma
- Acute alcohol, barbiturate and opiate intoxications
- This tablet should not be given to patients who have received an MAO-inhibitor within two weeks
- Not recommended for excitable or overactive patients since its activating effect may lead to exaggeration of these characteristics
Side Effects
In the recommended doses side effects are rare. These could be transient restlessness and insomnia.
Pregnancy & Lactation
This tablet should preferably not be given during pregnancy and lactation.
Precautions & Warnings
If previously the patient has been treated with tranquillizers with sedative effect these should be withdrawn gradually.
Overdose Effects
In cases of overdosage, the symptoms of intoxications by melitracen, especially of anticholinergic nature, dominate. More rarely extrapyramidal symptoms due to flupentixol occur. Symptomatic and Supportive. Gastric lavage should be carried out as soon as possible and activated charcoal may be administered. Measures aimed at supporting the respiratory and cardiovascular systems should be instituted. Epinephrine (adrenaline) must not be used for such patients. Convulsions may be treated with diazepam and extrapyramidal symptoms with biperiden.
Therapeutic Class
Combined anxiolytics & anti-depressant drugs
Storage Conditions
Store at a temperature not exceeding 30°C in a dry place. Protect from light. Keep out of reach of children.
Common Questions about Metflu 0.5 mg Tablet
- Metflu 0.5 mg Tablet consists of Flupentixol & Melitracen. It is used to treat Anxiety, Depression, Apathy, Psychogenic depression, Depressive neurosses, Masked depression, Menopausal depressions.
- Metflu 0.5 mg Tablet helps treat anxiety and depression. Use caution while driving or doing anything that requires concentration as it can cause dizziness and sleepiness. Avoid drinking alcohol while taking it because it can make drowsiness worse. It can cause changes in blood sugar levels. Monitor blood sugar regularly. Inform your doctor if you have liver disease, thyroid disorder, severe heart disease, or a urinary disorder. Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts. Let your doctor know you are taking it before undergoing any surgical procedure.